Simon C, Brandenberger G, Follenius M
J Clin Endocrinol Metab. 1987 Apr;64(4):669-74. doi: 10.1210/jcem-64-4-669.
The profiles of plasma glucose, insulin, and C-peptide were studied in normal men receiving continuous enteral nutrition. Large oscillations occurred with periods of 53-113 min. Their mean amplitudes, expressed as a percentage of the 24-h mean, were as high as 20% for glucose, 54% for insulin, and 56% for C-peptide. The oscillations of plasma insulin levels throughout the 24 h were concomitant with those of C-peptide. Rapid 8- to 14-min plasma insulin and glucose oscillations were smaller in magnitude and could only be detected in some segments of the longer period oscillations. These results indicate that in addition to the previously described 8- to 14-min oscillations, plasma glucose, insulin, and C-peptide oscillate at a mean 80-min periodicity in man during continuous enteral nutrition. These oscillations may reflect a pancreatic oscillatory mechanism and/or cyclic variations in gastrointestinal motility or peripheral glucose uptake.
对接受持续肠内营养的正常男性的血浆葡萄糖、胰岛素和C肽水平进行了研究。出现了周期为53 - 113分钟的大幅波动。其平均振幅，以24小时平均值的百分比表示，葡萄糖高达20%，胰岛素为54%，C肽为56%。24小时内血浆胰岛素水平的波动与C肽的波动同步。8至14分钟的快速血浆胰岛素和葡萄糖波动幅度较小，仅在较长周期波动的某些时段可检测到。这些结果表明，除了先前描述的8至14分钟的波动外，在持续肠内营养期间，人体血浆葡萄糖、胰岛素和C肽以平均80分钟的周期振荡。这些振荡可能反映了胰腺的振荡机制和/或胃肠蠕动或外周葡萄糖摄取的周期性变化。
