Ms Steven A Basham, Waldman PhD Hunter S, Krings PhD Ben M, Lamberth PhD John, Smith PhD JohnEric W, McAllister PhD Matthew J
Applied Physiology Lab, Department of Kinesiology, Mississippi State University, Starkville, MS, USA.
Department of Health and Human Performance, University of Wisconsin-Platteville, Platteville, WI, USA.
J Diet Suppl. 2020;17(4):401-414. doi: 10.1080/19390211.2019.1604604. Epub 2019 Apr 26.
Curcumin has been shown to reduce exercise-induced oxidative stress (OS) and inflammation. The purpose of this investigation was to examine the effects of curcumin supplementation on OS, inflammation, muscle damage, and muscle soreness. Nineteen males participated in a randomized, double-blinded, placebo-controlled trial to examine the effects of curcumin supplementation (1.5 g/day) compared to a placebo (PLA) following a muscle-damaging protocol (MDP) on OS, inflammation, muscle damage, and soreness. Participants were randomized to two groups, curcumin or placebo group. The MDP was performed before and after supplementation (28 days). Blood was sampled pre- and postexercise and 60 min, 24 h, and 48 h postexercise and analyzed for total antioxidant capacity (TAC), malondialdehyde (MDA), tumor necrosis factor alpha (TNF-α), and creatine kinase (CK). In addition, a visual analog scale (VAS) was used on each blood sample to measure perceived muscle soreness. After supplementation, curcumin significantly blunted CK levels (199.62 U/L) compared to the placebo (287.03 U/L), overall ( < 0.0001). In addition, curcumin resulted in decreased muscle soreness, overall (VAS scale 2.88), when compared to the placebo (VAS scale 3.36) ( = 0.0120). There were no differences found in TAC, TNF-α, or MDA. Curcumin may reduce muscle damage and perceived muscle soreness without negatively impacting a natural inflammatory response following exercise. Future research should investigate chronic curcumin supplementation and its mechanistic effects on muscle recovery from exercise.
姜黄素已被证明可减轻运动诱导的氧化应激（OS）和炎症。本研究的目的是检验补充姜黄素对OS、炎症、肌肉损伤和肌肉酸痛的影响。19名男性参与了一项随机、双盲、安慰剂对照试验，以检验在进行肌肉损伤方案（MDP）后，补充姜黄素（1.5克/天）与安慰剂（PLA）相比，对OS、炎症、肌肉损伤和酸痛的影响。参与者被随机分为两组，即姜黄素组或安慰剂组。在补充（28天）前后进行MDP。在运动前、运动后以及运动后60分钟、24小时和48小时采集血液样本，分析总抗氧化能力（TAC）、丙二醛（MDA）、肿瘤坏死因子α（TNF-α）和肌酸激酶（CK）。此外，对每个血液样本使用视觉模拟量表（VAS）来测量感知到的肌肉酸痛。补充后，与安慰剂（287.03 U/L）相比，姜黄素显著降低了CK水平（199.62 U/L），总体上（P<0.0001）。此外，与安慰剂（VAS量表评分为3.36）相比，姜黄素总体上导致肌肉酸痛减轻（VAS量表评分为2.88）（P = 0.0120）。在TAC、TNF-α或MDA方面未发现差异。姜黄素可能减轻肌肉损伤和感知到的肌肉酸痛，而不会对运动后的自然炎症反应产生负面影响。未来的研究应调查长期补充姜黄素及其对运动后肌肉恢复的机制性影响。
