Heart and Lung Department, Klinikum Fürth, Fürth, Germany.
Heart and Lung Department, Klinikum Fürth, Fürth, Germany.
Pharmacol Res. 2019 Jun;144:257-263. doi: 10.1016/j.phrs.2019.04.028. Epub 2019 Apr 23.
Quinidine has a very long history as antiarrhythmic medication. The alkaloid has been used in the treatment of almost all cardiac arrhythmias, especially atrial fibrillation, since the early twentieth century. Despite decreases in clinical prescription over the last two decades, mainly due to side effects like pro-arrhythmia, leading to increased mortality and to the availability of newer anti-arrhythmic drugs and catheter ablation, Quinidine remains an invaluable drug in the modern era of antiarrhythmic therapy. We present a review of the pharmacological properties of quinidine and its pivotal therapeutic role in the treatment of life-threatening arrhythmic storms in patients with congenital arrhythmogenic syndromes like Brugada's syndrome, early repolarization syndrome, short QT syndrome and idiopathic ventricular fibrillation.
奎尼丁作为抗心律失常药物已有很长的历史。自 20 世纪初以来，这种生物碱已被用于治疗几乎所有的心律失常，特别是心房颤动。尽管在过去二十年中临床处方有所减少，主要是由于致心律失常等副作用，导致死亡率增加，以及新型抗心律失常药物和导管消融术的出现，但奎尼丁在现代抗心律失常治疗时代仍然是一种非常宝贵的药物。我们回顾了奎尼丁的药理学特性及其在治疗 Brugada 综合征、早期复极综合征、短 QT 综合征和特发性心室颤动等先天性心律失常综合征患者的危及生命的心律失常风暴中的关键治疗作用。
