Li Yuanqiang, Li Boyu, Chen Wei-Dong, Wang Yan-Dong
State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China.
Department of Gastroenterology and Hematology, The People's Hospital of Hebi, Henan, China.
Front Cardiovasc Med. 2023 Jun 5;10:1130312. doi: 10.3389/fcvm.2023.1130312. eCollection 2023.
Cardiovascular diseases (CVDs) are the leading cause of death globally, with CVDs accounting for nearly 30% of deaths worldwide each year. G-protein-coupled receptors (GPCRs) are the most prominent family of receptors on the cell surface, and play an essential regulating cellular physiology and pathology. Some GPCR antagonists, such as β-blockers, are standard therapy for the treatment of CVDs. In addition, nearly one-third of the drugs used to treat CVDs target GPCRs. All the evidence demonstrates the crucial role of GPCRs in CVDs. Over the past decades, studies on the structure and function of GPCRs have identified many targets for the treatment of CVDs. In this review, we summarize and discuss the role of GPCRs in the function of the cardiovascular system from both vascular and heart perspectives, then analyze the complex ways in which multiple GPCRs exert regulatory functions in vascular and heart diseases. We hope to provide new ideas for the treatment of CVDs and the development of novel drugs.
心血管疾病（CVDs）是全球主要的死亡原因，每年全球近30%的死亡由心血管疾病导致。G蛋白偶联受体（GPCRs）是细胞表面最突出的受体家族，在调节细胞生理和病理过程中发挥着重要作用。一些GPCR拮抗剂，如β受体阻滞剂，是治疗心血管疾病的标准疗法。此外，近三分之一用于治疗心血管疾病的药物靶向GPCRs。所有证据都表明GPCRs在心血管疾病中起着关键作用。在过去几十年里，对GPCRs结构和功能的研究已经确定了许多治疗心血管疾病的靶点。在这篇综述中，我们从血管和心脏的角度总结并讨论GPCRs在心血管系统功能中的作用，然后分析多种GPCRs在血管和心脏疾病中发挥调节功能的复杂方式。我们希望为心血管疾病的治疗和新药开发提供新思路。
