Yang Felix, Hanon Sam, Lam Patrick, Schweitzer Paul
Beth Israel Medical Center, University Hospital for Albert Einstein College of Medicine, New York, NY 10003, USA.
Am J Med. 2009 Apr;122(4):317-21. doi: 10.1016/j.amjmed.2008.11.019. Epub 2009 Feb 25.
One of the earliest antiarrhythmic drugs developed, quinidine had a significant role in the treatment of many arrhythmias. After concerns for increased risk of ventricular arrhythmia and death with quinidine emerged, the use of quinidine fell dramatically in favor of newer antiarrhythmic medications. However, recent trials have generated renewed interest in the use of quinidine. In particular, quinidine appears to be safe and efficacious in combination with verapamil for the treatment of atrial fibrillation. Quinidine has also been used successfully to treat idiopathic ventricular fibrillation, Brugada syndrome, and Short QT syndrome. Although it is one of the oldest drugs in our armamentarium, quinidine continues to have a role in modern cardiology.
奎尼丁是最早研发的抗心律失常药物之一，在许多心律失常的治疗中发挥了重要作用。在出现对奎尼丁导致室性心律失常和死亡风险增加的担忧后，奎尼丁的使用量急剧下降，转而青睐更新的抗心律失常药物。然而，最近的试验重新引发了对使用奎尼丁的兴趣。特别是，奎尼丁与维拉帕米联合用于治疗心房颤动似乎是安全有效的。奎尼丁也已成功用于治疗特发性室性心动过速、 Brugada综合征和短QT综合征。尽管它是我们现有药物中最古老的药物之一，但奎尼丁在现代心脏病学中仍占有一席之地。
