Li Liubing, Chen Juanjuan, Chen Si, Liu Chenxi, Zhang Fengchun, Li Yongzhe
Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing.
Jiangxi Province Key Laboratory of Laboratory Medicine, Department of Clinical Laboratory, the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi.
Ann Clin Lab Sci. 2019 Mar;49(2):237-241.
C1q is an important component of the classical complement pathway. This study aimed to investigate C1q concentrations in the sera of PM/DM patients. C1q concentrations were measured in the sera of 87 PM/DM patients and 100 healthy subjects. In addition, the association between C1q concentration and laboratory indexes such as CK, AST, ALT, LDH, hsCRP, and ESR were also evaluated. Our data indicated no significant difference in the serum C1q concentration between PM/DM patients and healthy subjects. However, serum C1q concentrations were observed to be significantly higher in PM/DM patients in patients group with elevated ESR than in those with normal ESR (207.55±37.54 mg/L and 180.69±38.90 mg/L, respectively; =0.008). Furthermore, there was a positive correlation between serum C1q concentration and ESR (=0.002), but no association was observed with CK, AST, ALT, LDH, and hsCRP levels. This study demonstrated C1q levels were elevated in PM/DM patients with higher ESR and revealed significant positive correlation. However, the exact role of the classical complement pathway in PM/DM needs further elucidation.
C1q是经典补体途径的重要组成部分。本研究旨在调查皮肌炎（PM）/多发性肌炎（DM）患者血清中的C1q浓度。测定了87例PM/DM患者和100例健康受试者血清中的C1q浓度。此外，还评估了C1q浓度与肌酸激酶（CK）、天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）、乳酸脱氢酶（LDH）、超敏C反应蛋白（hsCRP）和红细胞沉降率（ESR）等实验室指标之间的关联。我们的数据表明，PM/DM患者与健康受试者血清中的C1q浓度无显著差异。然而，观察到红细胞沉降率升高的PM/DM患者组血清C1q浓度显著高于红细胞沉降率正常的患者组（分别为207.55±37.54mg/L和180.69±38.90mg/L；P=0.008）。此外，血清C1q浓度与红细胞沉降率呈正相关（P=0.002），但与CK、AST、ALT、LDH和hsCRP水平无关联。本研究表明，红细胞沉降率较高的PM/DM患者C1q水平升高，且呈显著正相关。然而，经典补体途径在PM/DM中的确切作用需要进一步阐明。
