Chen Si, Luan Haixia, He Jianxun, Wang Yan, Zeng Xiaoli, Li Yongzhe, Yuan Hui
Department of Clinical Laboratory Beijing Anzhen Hospital, Capital Medical University Beijing China.
Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College Chinese Academy of Medical Sciences Beijing China.
Health Sci Rep. 2021 Mar 23;4(2):e252. doi: 10.1002/hsr2.252. eCollection 2021 Jun.
C1q is a crucial component of the classical complement pathway. This study is the first to assess the association between disease activity and serum levels of C1q in Chinese Takayasu arteritis (TA) patients.
Serum C1q levels in 198 TA patients and 154 healthy controls were assessed, and the relationship between serum C1q levels and indices of TA disease activity was analyzed. Moreover, we examined the correlation between serum C1q levels and two traditional inflammatory biomarkers; erythrocyte sedimentation rate (ESR) and hypersensitive CRP (hs-CRP).
Serum C1q levels were increased in TA patients compared with healthy controls ( = .008). TA patients with active disease had higher levels of serum C1q than patients who had inactive disease ( < .0001). In addition, treatment-naïve patients had higher serum C1q levels than those who had been treated with corticosteroids or at least one immunosuppressant ( = .001). Furthermore, a positive correlation between serum C1q levels and traditional inflammatory biomarkers in TA patients was found. The role of C1q in assessing disease activity was studied, and the area under the receiver operating characteristic curve (AUC) of C1q for predicting active disease was 0.752, and a serum cutoff value of 167.15 mg/L C1q maximized the ability of disease activity assessment, with a sensitivity/specificity of 77.80%/64.90%. When the three indicators (C1q, ESR, and hs-CRP) were combined, the AUC increased to 0.845, and the sensitivity to 84.40%.
The serum C1q is associated with the disease activity of TA and the combination of three indicators (C1q, ESR, and hs-CRP) increases the sensitivity of disease activity assessment.
C1q是经典补体途径的关键组成部分。本研究首次评估中国大动脉炎（TA）患者疾病活动度与血清C1q水平之间的关联。
评估了198例TA患者和154例健康对照者的血清C1q水平，并分析了血清C1q水平与TA疾病活动度指标之间的关系。此外，我们还检测了血清C1q水平与两种传统炎症生物标志物（红细胞沉降率（ESR）和超敏C反应蛋白（hs-CRP））之间的相关性。
与健康对照相比，TA患者的血清C1q水平升高（P = 0.008）。活动期TA患者的血清C1q水平高于非活动期患者（P < 0.0001）。此外，未经治疗的患者血清C1q水平高于接受过皮质类固醇或至少一种免疫抑制剂治疗的患者（P = 0.001）。此外，还发现TA患者血清C1q水平与传统炎症生物标志物之间存在正相关。研究了C1q在评估疾病活动度中的作用，C1q预测活动期疾病的受试者工作特征曲线（AUC）下面积为0.752，血清C1q临界值为167.15mg/L时疾病活动度评估能力最大化，敏感性/特异性为77.80%/64.90%。当三项指标（C1q、ESR和hs-CRP）联合使用时，AUC增至0.845，敏感性提高至84.40%。
血清C1q与TA疾病活动度相关，三项指标（C1q、ESR和hs-CRP）联合使用可提高疾病活动度评估的敏感性。
