Department of General Surgery, Northern Jiangsu Province Hospital, Clinical Medical College, Institute of General Surgery - Yangzhou, Yangzhou University, Yangzhou, P.R. China.
Department of General Surgery, The Second Xiang ya Hospital of Central South University, Changsha, P.R. China.
Biosci Rep. 2019 May 17;39(5). doi: 10.1042/BSR20190357. Print 2019 May 31.
Gastric cancer is one of the most commonly diagnosed cancers each year, and it remains the third leading cause of cancer death in the world. The clinicopathologic characteristics differ among regions, so epigenetic changes play a key role in gastric carcinogenesis. In the present study, we first demonstrate that cardamonin, a natural production of chalcone, is an anti-gastric cancer agent in pre-clinical evaluation. Cardamonin inhibited proliferation and migration, induced apoptosis in gastric cancer cells. It could reduce the expression of apoptosis-related and migration-related genes and proteins. The constant activation of STAT3 (signal transducer and activator of transcription 3) signal is a major intrinsic signal for cancer inflammation. It regulates cellular proliferation, cell cycle, and migration that are critical for cancer procession. Cardamonin could effectively down-regulate p-STAT3 and abolish activation of STAT3 through inhibiting the expression of LncRNA-PVT1. The present study revealed that cardamonin is a potential natural source of anti-gastric cancer drugs via epigenetic mechanism to inhibit LncRNA-PVT1-STAT3 axis.
胃癌是每年最常见的癌症之一，它仍然是世界上癌症死亡的第三大主要原因。临床病理特征在不同地区有所不同，因此表观遗传变化在胃癌发生中起着关键作用。在本研究中，我们首先证明小豆蔻明，一种天然产生的查尔酮，是一种临床前评估的抗胃癌药物。小豆蔻明抑制增殖和迁移，诱导胃癌细胞凋亡。它可以降低凋亡相关和迁移相关基因和蛋白的表达。STAT3（信号转导和转录激活因子 3）信号的持续激活是癌症炎症的主要内在信号。它调节细胞增殖、细胞周期和迁移，这些对癌症进程至关重要。小豆蔻明可以通过抑制 LncRNA-PVT1 的表达，有效地下调 p-STAT3 并消除 STAT3 的激活。本研究揭示了小豆蔻明通过表观遗传机制抑制 LncRNA-PVT1-STAT3 轴，是一种潜在的天然抗胃癌药物来源。
