Pineda A A, Rippeteau N D, Clare D E, Bunkowske B M
Mayo Clin Proc. 1987 Mar;62(3):199-202. doi: 10.1016/s0025-6196(12)62442-2.
We compared the flow rates of whole blood and erythrocytes resuspended in a new preservative solution (AS-1, consisting of adenine, dextrose, mannitol, and saline) which results in an erythrocyte preparation with a hematocrit lower than that of packed erythrocytes. When 100 ml of AS-1 solution is added to erythrocytes, a hematocrit of 59 +/- 5% is consistently obtained, and the resultant product has an improved flow rate. When we compared the infusion flow rates of whole blood and AS-1-preserved erythrocytes in vitro and in vivo, we found that flow times were shorter for AS-1 erythrocytes than for whole blood in vitro and in vivo, the flow rates of AS-1 erythrocytes and whole blood when expressed per volume were similar in vivo, and the flow rate of AS-1 erythrocytes for erythrocyte mass delivery in vivo was superior to that of whole blood. Thus, we conclude that the flow rates of the two products are comparable.
我们比较了全血和悬浮于一种新型保存液（AS - 1，由腺嘌呤、葡萄糖、甘露醇和生理盐水组成）中的红细胞的流速，该保存液会使红细胞制剂的血细胞比容低于浓缩红细胞。当向红细胞中加入100毫升AS - 1溶液时，始终能得到血细胞比容为59±5%的结果，且所得产品的流速有所改善。当我们在体外和体内比较全血与AS - 1保存的红细胞的输注流速时，发现AS - 1红细胞在体外和体内的流动时间均短于全血，AS - 1红细胞和全血按体积计算的体内流速相似，并且AS - 1红细胞在体内用于输送红细胞量的流速优于全血。因此，我们得出结论，这两种产品的流速具有可比性。
