Naumova L A, Osipova O N, Klinnikova M G
Institute of Medicine, Surgut State University, Surgut, Russia.
Institute of Molecular Pathology and Pathomorphology, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia.
Bull Exp Biol Med. 2019 Apr;166(6):774-778. doi: 10.1007/s10517-019-04438-8. Epub 2019 Apr 26.
We performed immunohistochemical analysis of the expression of TGFβ, galectin-1, vimentin, and thrombospondin in the mucosa in gastric cancer of diffuse and intestinal type associated with systemic undifferentiated connective tissue dysplasia. In diffuse gastric cancer, both with and without association with connective tissue dysplasia, a higher level of expression of TGFβ, galectin-1, vimentin, and thrombospondin in the tumor was detected in comparison with the perifocal and tumor zones in intestinal gastric cancer, which may reflect the pathogenetic peculiarities of the two histotypes of gastric cancer. Intestinal type of gastric cancer associated with connective tissue dysplasia is characterized by a high level of expression of galectin-1 and vimentin in the perifocal zone and TGFβ in the tumor zone. The pattern of expression of the studied markers can reflect both the pathogenetic peculiarities of the two histotypes of gastric cancer and peculiar expression of some growth factors, cytoskeleton proteins, and matrix-cell proteins associated with undifferentiated connective tissue dysplasia which may contribute to epithelial-mesenchymal transition.
我们对弥漫型和肠型胃癌黏膜中转化生长因子β（TGFβ）、半乳糖凝集素-1、波形蛋白和血小板反应蛋白的表达进行了免疫组化分析，这些胃癌与全身性未分化结缔组织发育异常相关。在弥漫型胃癌中，无论是否与结缔组织发育异常相关，与肠型胃癌的瘤周和肿瘤区域相比，肿瘤中TGFβ、半乳糖凝集素-1、波形蛋白和血小板反应蛋白的表达水平更高，这可能反映了两种组织学类型胃癌的发病机制特点。与结缔组织发育异常相关的肠型胃癌的特征是瘤周区域半乳糖凝集素-1和波形蛋白表达水平高，肿瘤区域TGFβ表达水平高。所研究标志物的表达模式既可以反映两种组织学类型胃癌的发病机制特点，也可以反映与未分化结缔组织发育异常相关的一些生长因子、细胞骨架蛋白和基质细胞蛋白的特殊表达，这可能有助于上皮-间质转化。
