Brzozowa-Zasada Marlena, Wyrobiec Grzegorz, Piecuch Adam, Jasiński Dawid
Department of Histology and Cell Pathology, Medical Faculty in Zabrze, Medical University of Silesia in Katowice, Poland.
Prz Gastroenterol. 2022;17(2):123-129. doi: 10.5114/pg.2022.116408. Epub 2022 Jun 1.
It is generally accepted that colon cancer is the most commonly diagnosed gastrointestinal cancer and a major public health problem. As revealed by studies, the clinical outcomes of patients, especially those with lymph node-positive status, are still unsatisfactory.
The current study investigated the expression of vimentin protein in colon adenocarcinoma samples from proximal and distal parts of the colon to assess its prognostic significance by correlating its immunohistochemical expression with the clinicopathological variables and survival of Caucasian patients.
To investigate the clinicopathological and prognostic roles of vimentin expression, the immunohistochemical analysis was performed in colon cancer tumour samples and adjacent non- pathological mucosa. As revealed, the level of vimentin immunohistochemical reactivity correlated with the grade of the histological differentiation (H [2.97] = 37.949; < 0.001).
The Kaplan-Meier survival analysis showed that the overall survival rate in the group of patients with low vimentin immunoreactivity was significantly greater than that for patients with a moderate or strong level of vimentin protein expression. Multivariate analysis demonstrated that the grade of tumour differentiation (HR = 2.150; 95% CI: 1.380-3.349, = 0.001) and vimentin expression (HR = 3.901; 95% CI: 2.436-6.247, < 0.001) were independent risk factors for worse survival.
人们普遍认为结肠癌是最常被诊断出的胃肠道癌症，也是一个重大的公共卫生问题。研究表明，患者的临床结局，尤其是那些淋巴结阳性状态的患者，仍然不尽人意。
本研究调查了波形蛋白在结肠近端和远端腺癌样本中的表达情况，通过将其免疫组化表达与白种人患者的临床病理变量及生存率相关联，评估其预后意义。
为了研究波形蛋白表达的临床病理和预后作用，对结肠癌肿瘤样本及相邻非病理黏膜进行了免疫组化分析。结果显示，波形蛋白免疫组化反应水平与组织学分化程度相关（H[2.97]=37.949；<0.001）。
Kaplan-Meier生存分析表明，波形蛋白免疫反应性低的患者组总生存率显著高于波形蛋白表达水平为中度或强阳性的患者。多因素分析表明，肿瘤分化程度（HR=2.150；95%CI：1.380-3.349，=0.001）和波形蛋白表达（HR=3.901；95%CI：2.436-6.247，<0.001）是生存较差的独立危险因素。
