低剂量率和超高剂量率γ辐射对淋巴细胞及培养的人恶性淋巴瘤细胞生物学效应的比较
Comparison of Biological Effects of γ-Radiation of Low and Ultra-High Dose Rate on Lymphocytes and Cultured Human Malignant Lymphoma Cells.
作者信息
Bozhenko V K, Ivanov A V, Kulinich T M, Smirnov V P, Shishkin A M, Solodky V A
机构信息
Russian Scientific Center of Roentgenoradiology, Ministry of Health of the Russian Federation, Moscow, Russia.
出版信息
Bull Exp Biol Med. 2019 Apr;166(6):785-787. doi: 10.1007/s10517-019-04440-0. Epub 2019 Apr 26.
We studied the effect of low and high-dose rate photon radiation on activation of cell death by apoptosis and necrosis in malignant cell lines of lymphocytic origin Raji and Jurkat (human B and T-cell lymphomas) and normal human lymphocytes from healthy volunteers. It was shown that photon radiation with ultra-high dose rate induced significantly higher levels of "early" apoptosis and lower levels of necrosis compared to γ-radiation with dose rate used for radiation therapy.
我们研究了低剂量率和高剂量率光子辐射对淋巴细胞起源的恶性细胞系Raji和Jurkat（人B细胞和T细胞淋巴瘤）以及健康志愿者的正常人淋巴细胞中细胞凋亡和坏死导致的细胞死亡激活的影响。结果表明，与用于放射治疗的剂量率的γ辐射相比，超高剂量率的光子辐射诱导的“早期”凋亡水平显著更高，坏死水平更低。
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