FLASH效应的机制。
Mechanisms of FLASH effect.
作者信息
Lin Binwei, Huang Dan, Gao Feng, Yang Yiwei, Wu Dai, Zhang Yu, Feng Gang, Dai Tangzhi, Du Xiaobo
机构信息
National Health Commission (NHC) Key Laboratory of Nuclear Technology Medical Transformation, Mianyang Central Hospital, Department of Oncology, Mianyang Central Hospital, Mianyang, China.
State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, China.
出版信息
Front Oncol. 2022 Sep 23;12:995612. doi: 10.3389/fonc.2022.995612. eCollection 2022.
FLASH radiotherapy (FLASH-RT) is a novel radiotherapy technology defined as ultra-high dose rate (≥ 40 Gy/s) radiotherapy. The biological effects of FLASH-RT include two aspects: first, compared with conventional dose rate radiotherapy, FLASH-RT can reduce radiation-induced damage in healthy tissue, and second, FLASH-RT can retain antitumor effectiveness. Current research shows that mechanisms of the biological effects of FLASH-RT are related to oxygen. However, due to the short time of FLASH-RT, evidences related to the mechanisms are indirect, and the exact mechanisms of the biological effects of FLASH-RT are not completely clear and some are even contradictory. This review focuses on the mechanisms of the biological effects of FLASH-RT and proposes future research directions.
闪速放疗（FLASH-RT）是一种新型放疗技术，定义为超高剂量率（≥40 Gy/s）放疗。FLASH-RT的生物学效应包括两个方面：第一，与传统剂量率放疗相比，FLASH-RT可减少健康组织中的辐射诱导损伤；第二，FLASH-RT可保留抗肿瘤效果。目前的研究表明，FLASH-RT生物学效应的机制与氧有关。然而，由于FLASH-RT时间较短，与这些机制相关的证据是间接的，FLASH-RT生物学效应的确切机制尚不完全清楚，有些甚至相互矛盾。本综述聚焦于FLASH-RT生物学效应的机制，并提出未来的研究方向。
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