• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

卵巢癌中组成型光形态建成蛋白1（COP1）与p27肿瘤抑制蛋白表达的相关性

Correlation of constitutive photomorphogenic 1 (COP1) and p27 tumor suppressor protein expression in ovarian cancer.

作者信息

Ko Eun-Ji, Oh Young Lim, Kim Heung Yeol, Eo Wan Kyu, Kim Hongbae, Kim Ki Hyung, Koh Suk Bong, Ock Mee Sun, Choi Yung Hyun, Kim Ari, Choi Hyun Ho, Park Eun Joo, Cha Hee-Jae

机构信息

Department of Parasitology and Genetics, Kosin University College of Medicine, Busan, Republic of Korea.

Department of Biological Sciences, College of Natural Sciences, Pusan National University, Busan, Republic of Korea.

出版信息

Genes Genomics. 2019 Aug;41(8):879-884. doi: 10.1007/s13258-019-00818-6. Epub 2019 Apr 26.

DOI:10.1007/s13258-019-00818-6
PMID:31028655
Abstract

BACKGROUND

Constitutive photomorphogenic 1 (COP1) is an E3 ubiquitin ligase that regulates important target proteins for cell growth including p27. The tumor suppressor p27 negatively regulates the cell cycle by inhibiting cyclin-dependent kinase. COP1 negatively regulates p27 stability by mediating its nuclear export and degradation.

OBJECTIVE

Even if COP1 and p27 are tightly related and have significant roles in tumor progression, the expression patterns and relationship of both proteins in cancer have not yet been studied.

METHOD

We analyzed the expression patterns and relationship between COP1 and p27 using an ovarian cancer tissue microarray by dual immunofluorescence analysis.

RESULTS

The expression levels of COP1 and p27 proteins were not significantly different between ovarian cancer tissue and normal control tissue. Other clinical data including age, tumor type, tumor grade, and stage were not significantly related to expression of the two proteins. The co-relationship between COP1 and p27 proteins was significantly high (Pearson correlation coefficient 0.79, p = 8.65 × 10).

CONCLUSIONS

Our results demonstrate that while the expression levels of COP1 and p27 are highly correlated, they are not significantly related to cancer progression in ovarian cancer.

摘要

背景

组成型光形态建成1（COP1）是一种E3泛素连接酶，可调节包括p27在内的细胞生长重要靶蛋白。肿瘤抑制因子p27通过抑制细胞周期蛋白依赖性激酶来负向调节细胞周期。COP1通过介导p27的核输出和降解来负向调节其稳定性。

目的

尽管COP1和p27密切相关且在肿瘤进展中具有重要作用，但尚未对这两种蛋白在癌症中的表达模式及关系进行研究。

方法

我们通过双免疫荧光分析，利用卵巢癌组织芯片分析了COP1和p27之间的表达模式及关系。

结果

卵巢癌组织与正常对照组织中COP1和p27蛋白的表达水平无显著差异。包括年龄、肿瘤类型、肿瘤分级和分期在内的其他临床数据与这两种蛋白的表达无显著相关性。COP1和p27蛋白之间的共关系显著较高（皮尔逊相关系数0.79，p = 8.65×10）。

结论

我们的结果表明，虽然COP1和p27的表达水平高度相关，但它们与卵巢癌的癌症进展无显著相关性。

相似文献

1
Correlation of constitutive photomorphogenic 1 (COP1) and p27 tumor suppressor protein expression in ovarian cancer.卵巢癌中组成型光形态建成蛋白1（COP1）与p27肿瘤抑制蛋白表达的相关性
Genes Genomics. 2019 Aug;41(8):879-884. doi: 10.1007/s13258-019-00818-6. Epub 2019 Apr 26.
2
Regulating the stability and localization of CDK inhibitor p27(Kip1) via CSN6-COP1 axis.通过CSN6-COP1轴调控细胞周期蛋白依赖性激酶抑制剂p27（Kip1）的稳定性和定位。
Cell Cycle. 2015;14(14):2265-73. doi: 10.1080/15384101.2015.1046655. Epub 2015 May 6.
3
COP1 enhances ubiquitin-mediated degradation of p27Kip1 to promote cancer cell growth.COP1增强p27Kip1的泛素介导降解以促进癌细胞生长。
Oncotarget. 2015 Aug 14;6(23):19721-34. doi: 10.18632/oncotarget.3821.
4
The ubiquitin ligase COP1 regulates cell cycle and apoptosis by affecting p53 function in human breast cancer cell lines.泛素连接酶 COP1 通过影响人乳腺癌细胞系中 p53 的功能来调节细胞周期和细胞凋亡。
Breast Cancer. 2018 Sep;25(5):529-538. doi: 10.1007/s12282-018-0849-5. Epub 2018 Mar 7.
5
Constitutive photomorphogenesis protein 1 (COP1) and COP9 signalosome, evolutionarily conserved photomorphogenic proteins as possible targets of melatonin.组成型光形态建成蛋白 1（COP1）和 COP9 信号体，作为褪黑素的可能作用靶点的进化上保守的光形态建成蛋白。
J Pineal Res. 2016 Aug;61(1):41-51. doi: 10.1111/jpi.12340. Epub 2016 Jun 13.
6
E6AP promotes prostate cancer by reducing p27 expression.E6AP通过降低p27表达促进前列腺癌。
Oncotarget. 2017 Jun 27;8(26):42939-42948. doi: 10.18632/oncotarget.17224.
7
Role of the COP1 protein in cancer development and therapy.COP1 蛋白在癌症发生和治疗中的作用。
Semin Cancer Biol. 2020 Dec;67(Pt 2):43-52. doi: 10.1016/j.semcancer.2020.02.001. Epub 2020 Feb 3.
8
p27(Kip1) signaling: Transcriptional and post-translational regulation.p27（Kip1）信号传导：转录和翻译后调控。
Int J Biochem Cell Biol. 2015 Nov;68:9-14. doi: 10.1016/j.biocel.2015.08.005. Epub 2015 Aug 14.
9
CSN6 deregulation impairs genome integrity in a COP1-dependent pathway.CSN6失调通过一种依赖COP1的途径损害基因组完整性。
Oncotarget. 2015 May 20;6(14):11779-93. doi: 10.18632/oncotarget.3151.
10
PCBP1 depletion promotes tumorigenesis through attenuation of p27 mRNA stability and translation.PCBP1 耗竭通过衰减 p27 mRNA 的稳定性和翻译促进肿瘤发生。
J Exp Clin Cancer Res. 2018 Aug 7;37(1):187. doi: 10.1186/s13046-018-0840-1.

引用本文的文献

1
Acute Myeloid Leukemia-Related Proteins Modified by Ubiquitin and Ubiquitin-like Proteins.泛素和类泛素蛋白修饰的急性髓系白血病相关蛋白。
Int J Mol Sci. 2022 Jan 3;23(1):514. doi: 10.3390/ijms23010514.
2
Targeting RFWD2 as an Effective Strategy to Inhibit Cellular Proliferation and Overcome Drug Resistance to Proteasome Inhibitor in Multiple Myeloma.靶向RFWD2作为抑制多发性骨髓瘤细胞增殖和克服对蛋白酶体抑制剂耐药性的有效策略。
Front Cell Dev Biol. 2021 Apr 21;9:675939. doi: 10.3389/fcell.2021.675939. eCollection 2021.
3
Cellular Functions of OCT-3/4 Regulated by Ubiquitination in Proliferating Cells.

本文引用的文献

1
The ubiquitin ligase COP1 regulates cell cycle and apoptosis by affecting p53 function in human breast cancer cell lines.泛素连接酶 COP1 通过影响人乳腺癌细胞系中 p53 的功能来调节细胞周期和细胞凋亡。
Breast Cancer. 2018 Sep;25(5):529-538. doi: 10.1007/s12282-018-0849-5. Epub 2018 Mar 7.
2
COP1 is downregulated in renal cell carcinoma (RCC) and inhibits the migration of RCC ACHN cells in vitro.在肾细胞癌（RCC）中，COP1表达下调，且在体外抑制肾细胞癌ACHN细胞的迁移。
Mol Med Rep. 2016 Aug;14(2):1371-8. doi: 10.3892/mmr.2016.5373. Epub 2016 Jun 7.
3
Regulating the stability and localization of CDK inhibitor p27(Kip1) via CSN6-COP1 axis.
泛素化调控增殖细胞中OCT-3/4的细胞功能
Cancers (Basel). 2020 Mar 12;12(3):663. doi: 10.3390/cancers12030663.
通过CSN6-COP1轴调控细胞周期蛋白依赖性激酶抑制剂p27（Kip1）的稳定性和定位。
Cell Cycle. 2015;14(14):2265-73. doi: 10.1080/15384101.2015.1046655. Epub 2015 May 6.
4
COP1, the negative regulator of ETV1, influences prognosis in triple-negative breast cancer.ETV1的负调控因子COP1影响三阴性乳腺癌的预后。
BMC Cancer. 2015 Mar 15;15:132. doi: 10.1186/s12885-015-1151-y.
5
Mislocalization of p27 to the cytoplasm of breast cancer cells confers resistance to anti-HER2 targeted therapy.p27在乳腺癌细胞胞质中的定位错误赋予了对抗HER2靶向治疗的抗性。
Oncotarget. 2014 Dec 30;5(24):12704-14. doi: 10.18632/oncotarget.2871.
6
TRIB2 inhibits Wnt/β-Catenin/TCF4 signaling through its associated ubiquitin E3 ligases, β-TrCP, COP1 and Smurf1, in liver cancer cells.TRIB2 通过其关联的泛素 E3 连接酶 β-TrCP、COP1 和 Smurf1 在肝癌细胞中抑制 Wnt/β-连环蛋白/TCF4 信号通路。
FEBS Lett. 2014 Nov 28;588(23):4334-41. doi: 10.1016/j.febslet.2014.09.042. Epub 2014 Oct 13.
7
High p27 protein levels in chronic lymphocytic leukemia are associated to low Myc and Skp2 expression, confer resistance to apoptosis and antagonize Myc effects on cell cycle.慢性淋巴细胞白血病中高p27蛋白水平与低Myc和Skp2表达相关，赋予细胞对凋亡的抗性，并拮抗Myc对细胞周期的影响。
Oncotarget. 2014 Jul 15;5(13):4694-708. doi: 10.18632/oncotarget.2100.
8
COP1 and GSK3β cooperate to promote c-Jun degradation and inhibit breast cancer cell tumorigenesis.COP1 和 GSK3β 合作促进 c-Jun 降解并抑制乳腺癌细胞的肿瘤发生。
Neoplasia. 2013 Sep;15(9):1075-85. doi: 10.1593/neo.13966.
9
Loss of COP1 expression determines poor prognosisin patients with gastric cancer.COP1 表达缺失决定了胃癌患者的不良预后。
Oncol Rep. 2013 Oct;30(4):1971-5. doi: 10.3892/or.2013.2664. Epub 2013 Aug 8.
10
Cyclin D1 predicts the prognosis of advanced serous ovarian cancer.细胞周期蛋白D1可预测晚期浆液性卵巢癌的预后。
Exp Ther Med. 2011 Mar;2(2):213-219. doi: 10.3892/etm.2011.194. Epub 2011 Jan 18.