ICOA UMR CNRS 7311, Université d'Orléans, Rue de Chartres, 45067 Orléans, France.
ICOA UMR CNRS 7311, Université d'Orléans, Rue de Chartres, 45067 Orléans, France.
Mater Sci Eng C Mater Biol Appl. 2019 Aug;101:254-263. doi: 10.1016/j.msec.2019.03.102. Epub 2019 Mar 28.
Herein, we propose the synthesis of a microspherical imprinted hydrogel meant for the controlled release of a nucleotide, adenosine 5'-monophosphate (5'-AMP). Indeed, molecularly imprinted polymers-based (MIPs) materials possess remarkable selective molecular recognition ability that mimicks biological systems. MIPs have been used in numerous applications and hold great promise for the vectorization and/or controlled release of therapeutics and cosmetics. But, the conception of imprinted hydrogels-based drug delivery systems that are able to release polar bioactive compounds is explored weakly. Herein, the synthesis of imprinted hydrogel microbeads by inverse Pickering emulsion is detailed. Microspheres showed a large 5'-AMP loading capacity, around 300 mg·g, and a high binding capacity comparatively to the non-imprinted counterpart. The MIP had a thermo-responsive release behavior providing sustained release of adenosine 5'-monophosphate in an aqueous buffer simulating both human skin pH and temperature.
在此，我们提出了一种用于控制核苷酸（腺苷 5'-单磷酸（5'-AMP））释放的微球印迹水凝胶的合成方法。事实上，基于分子印迹聚合物（MIPs）的材料具有模仿生物系统的显著选择性分子识别能力。MIPs 已被应用于许多领域，并在治疗剂和化妆品的载体化和/或控制释放方面具有很大的应用前景。但是，能够释放极性生物活性化合物的印迹水凝胶药物传递系统的构想研究还很薄弱。本文详细介绍了通过反相 Pickering 乳液法合成印迹水凝胶微球。微球表现出较高的 5'-AMP 负载能力，约为 300mg·g，与非印迹对应物相比，具有较高的结合能力。MIP 具有温度响应性释放行为，在模拟人体皮肤 pH 值和温度的水性缓冲液中提供腺苷 5'-单磷酸的持续释放。
