Department of Physics and Astronomy, University of Texas at San Antonio, TX 78249, United States of America.
Department of Physics and Astronomy, University of Texas at San Antonio, TX 78249, United States of America.
Mater Sci Eng C Mater Biol Appl. 2019 Aug;101:283-291. doi: 10.1016/j.msec.2019.03.085. Epub 2019 Mar 25.
Nanomaterials with multiple imaging functionalities are nowadays getting tremendous attention due to their several superior features compared to existing contrast agents. By developing a nanomaterial that exhibit multiple functionalities, the possibility to increase the amount of imaging information obtained in a short amount of time is becoming more and more a reality. In this work, we developed a multifunctional nanocrystals (NCs), Na(GdLu)F:Nd, that combines multiple rare-earth features as an all-in-one imaging agent comprised of optical imaging, magnetic imaging, and X-ray imaging by utilizing the superparamagnetic features of Gd, the high X-ray absorption cross section of Lu, and the NIR fluorescence of Nd. Morphology, optical properties, and cell viability are shown in detail where the utility of this multifunctional imaging agent was confirmed by optical, X-ray and magnetic imaging experiments. Surface functionalization of the NCs is also presented to highlight the potential application of the NCs as contrast agents in biological imaging.
由于与现有对比剂相比具有多种优越特性，具有多种成像功能的纳米材料如今受到了极大的关注。通过开发具有多种功能的纳米材料，在短时间内获得更多成像信息的可能性越来越成为现实。在这项工作中，我们开发了一种多功能纳米晶体（NCs），Na(GdLu)F:Nd，它将多种稀土特性结合在一起，作为一种集光学成像、磁共振成像和 X 射线成像于一体的成像剂，利用 Gd 的超顺磁性、Lu 的高 X 射线吸收截面和 Nd 的近红外荧光。详细展示了其形态、光学性质和细胞活力，通过光学、X 射线和磁共振成像实验证实了这种多功能成像剂的实用性。还介绍了 NCs 的表面功能化，以突出 NCs 作为生物成像对比剂的潜在应用。
