State Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China.
School of Biomedical Engineering, University of Technology Sydney, P. O. Box 123, NSW 2007, Australia.
Mater Sci Eng C Mater Biol Appl. 2019 Aug;101:650-659. doi: 10.1016/j.msec.2019.04.021. Epub 2019 Apr 9.
Supramolecular-based nanofibers, which successfully combine the unique properties of supramolecular interactions with the advantages of nanofibrous structure, are widely used in a variety of biomedical applications such as controlled drug delivery. Compared with traditional polymer nanofibers, supramolecular-based nanofibers can overcome the bottleneck of sensitivity because of the non-covalent binding modes, and therefore match the requirements of rapid and reversible response to the external stimuli. In addition, supramolecular-based nanofibers can achieve extra controllable and dynamic responsive (e.g. pH, temperature) functions in different environments. In this review, we retrospected and summarized the recent development of supramolecular-based nanofibers, focusing particularly on electrospun supramolecular nanofibers, while also touching on the advances of directly self-assembled supramolecular nanofibers without the use of electrospinning. Furthermore, we discussed the potential biomedical applications of supramolecular nanofibers. Finally, this review was concluded by elaborating upon individual reflection on the current situation, forecasting the future trend of this promising material.
基于超分子的纳米纤维成功地将超分子相互作用的独特性质与纳米纤维结构的优势结合在一起，广泛应用于各种生物医学应用中，如控制药物释放。与传统的聚合物纳米纤维相比，基于超分子的纳米纤维可以克服非共价键结合模式的灵敏度瓶颈，因此符合对外界刺激快速和可逆响应的要求。此外，基于超分子的纳米纤维可以在不同的环境中实现额外的可控和动态响应（例如 pH 值、温度）功能。在这篇综述中，我们回顾和总结了基于超分子的纳米纤维的最新发展，特别关注静电纺丝超分子纳米纤维，同时也涉及到不使用静电纺丝直接自组装的超分子纳米纤维的进展。此外，我们讨论了超分子纳米纤维的潜在生物医学应用。最后，本文通过详细阐述对当前情况的个人反思，预测了这种有前途的材料的未来趋势。
