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负载生物活性化合物的电纺食品多糖:制备、释放及应用

Electrospun Food Polysaccharides Loaded with Bioactive Compounds: Fabrication, Release, and Applications.

作者信息

Lin Zhenyu, Chen Hao, Li Shengmei, Li Xiaolu, Wang Jie, Xu Shanshan

机构信息

Institute for Advanced Study, Shenzhen University, Shenzhen 518060, China.

Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.

出版信息

Polymers (Basel). 2023 May 16;15(10):2318. doi: 10.3390/polym15102318.

Abstract

Food polysaccharides are well acclaimed in the field of delivery systems due to their natural safety, biocompatibility with the human body, and capability of incorporating/releasing various bioactive compounds. Electrospinning, a straightforward atomization technique that has been attracting researchers worldwide, is also versatile for coupling food polysaccharides and bioactive compounds. In this review, several popular food polysaccharides including starch, cyclodextrin, chitosan, alginate, and hyaluronic acid are selected to discuss their basic characteristics, electrospinning conditions, bioactive compound release characteristics, and more. Data revealed that the selected polysaccharides are capable of releasing bioactive compounds from as rapidly as 5 s to as prolonged as 15 days. In addition, a series of frequently studied physical/chemical/biomedical applications utilizing electrospun food polysaccharides with bioactive compounds are also selected and discussed. These promising applications include but are not limited to active packaging with 4-log reduction against , and ; removal of 95% of particulate matter (PM) 2.5 and volatile organic compounds (VOCs); heavy metal ion removal; increasing enzyme heat/pH stability; wound healing acceleration and enhanced blood coagulation, etc. The broad potentials of electrospun food polysaccharides loaded with bioactive compounds are demonstrated in this review.

摘要

食品多糖因其天然安全性、与人体的生物相容性以及结合/释放各种生物活性化合物的能力,在递送系统领域广受赞誉。静电纺丝是一种简单的雾化技术,一直吸引着世界各地的研究人员,它在耦合食品多糖和生物活性化合物方面也具有通用性。在这篇综述中,选择了几种常见的食品多糖,包括淀粉、环糊精、壳聚糖、藻酸盐和透明质酸,来讨论它们的基本特性、静电纺丝条件、生物活性化合物释放特性等。数据显示,所选多糖能够在5秒至长达15天的时间内释放生物活性化合物。此外,还选择并讨论了一系列利用含有生物活性化合物的静电纺丝食品多糖进行的经常研究的物理/化学/生物医学应用。这些有前景的应用包括但不限于对 、 和 有4个对数级减少的活性包装;去除95%的细颗粒物(PM)2.5和挥发性有机化合物(VOCs);去除重金属离子;提高酶的热/ pH稳定性;加速伤口愈合和增强血液凝固等。这篇综述展示了负载生物活性化合物的静电纺丝食品多糖的广阔潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/769b/10221597/cb7727df1da2/polymers-15-02318-g002.jpg

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