载适体的聚二乙酰苯胶束提高了对癌细胞的靶向性。
Aptamer-decorated polydiacetylene micelles with improved targeting of cancer cells.
机构信息
Service de Chimie Bioorganique et de Marquage (SCBM), CEA, Université Paris-Saclay, 91191 Gif-sur-Yvette, France.
Molecular Imaging Research Center (MIRCen), CEA, Université Paris-Saclay, UMR9199, 92265 Fontenay-aux-Roses, France.
出版信息
Int J Pharm. 2019 Jun 30;565:59-63. doi: 10.1016/j.ijpharm.2019.04.071. Epub 2019 Apr 25.
In this study, a "click and hybridization" strategy was developed for the functionalization of polydiacetylene micelles with a targeting aptamer ligand. Decoration of the nanocarriers with an anti-Annexin A2 sequence efficiently triggered enhanced internalization of the functionalized micelles in the MCF-7 cell line, with a marked increase compared to control micelles.
在这项研究中，开发了一种“点击和杂交”策略，用于将靶向适配体配体功能化聚二乙炔胶束。用抗膜联蛋白 A2 序列修饰纳米载体可有效触发功能化胶束在 MCF-7 细胞系中的增强内化，与对照胶束相比，内化显著增加。
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