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非裔哮喘患者中存在白细胞介素 6 高表型哮喘的证据。

Evidence for an IL-6-high asthma phenotype in asthmatic patients of African ancestry.

机构信息

Department of Medicine, University of Chicago, Chicago, Ill.

Department of Medicine, University of Chicago, Chicago, Ill.

出版信息

J Allergy Clin Immunol. 2019 Jul;144(1):304-306.e4. doi: 10.1016/j.jaci.2019.04.007. Epub 2019 Apr 25.

DOI:10.1016/j.jaci.2019.04.007
PMID:31029772
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6612296/
Abstract

High circulating IL-6 may define a phenotype of asthma associated with obesity and systemic inflammation. We demonstrate that circulating IL-6 is higher in African-American patients with asthma, and that race-specific thresholds should be considered.

摘要

高循环白细胞介素 6 可能定义了一种与肥胖和全身炎症相关的哮喘表型。我们证明，患有哮喘的非裔美国患者的循环白细胞介素 6 水平更高，因此应该考虑种族特异性的阈值。

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本文引用的文献

1
Elevated levels of soluble humanleukocyte antigen-G in the airways are a marker for a low-inflammatory endotype of asthma.气道中可溶性人白细胞抗原-G 水平升高是哮喘低炎症表型的标志物。
J Allergy Clin Immunol. 2017 Sep;140(3):857-860. doi: 10.1016/j.jaci.2017.02.031. Epub 2017 Mar 28.
2
Metabolic Syndrome Prevalence by Race/Ethnicity and Sex in the United States, National Health and Nutrition Examination Survey, 1988-2012.1988 - 2012年美国国家健康与营养检查调查中按种族/族裔和性别划分的代谢综合征患病率
Prev Chronic Dis. 2017 Mar 16;14:E24. doi: 10.5888/pcd14.160287.
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Systemic Inflammation in Midlife: Race, Socioeconomic Status, and Perceived Discrimination.中年时期的全身性炎症：种族、社会经济地位与感知到的歧视
Am J Prev Med. 2017 Jan;52(1S1):S63-S76. doi: 10.1016/j.amepre.2016.09.026.
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DNA methylation in lung cells is associated with asthma endotypes and genetic risk.肺细胞中的 DNA 甲基化与哮喘表型和遗传风险有关。
JCI Insight. 2016 Dec 8;1(20):e90151. doi: 10.1172/jci.insight.90151.
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Association between obesity and asthma - epidemiology, pathophysiology and clinical profile.肥胖与哮喘的关联：流行病学、病理生理学和临床特征。
Nutr Res Rev. 2016 Dec;29(2):194-201. doi: 10.1017/S0954422416000111. Epub 2016 Aug 12.
6
Plasma interleukin-6 concentrations, metabolic dysfunction, and asthma severity: a cross-sectional analysis of two cohorts.血浆白细胞介素-6 浓度、代谢功能障碍与哮喘严重程度：两个队列的横断面分析。
Lancet Respir Med. 2016 Jul;4(7):574-584. doi: 10.1016/S2213-2600(16)30048-0. Epub 2016 Jun 6.
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Type 2 inflammation in asthma--present in most, absent in many.哮喘中的2型炎症——多数存在，许多不存在。
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Inflammatory links between obesity and metabolic disease.肥胖与代谢性疾病之间的炎症关联。
J Clin Invest. 2011 Jun;121(6):2111-7. doi: 10.1172/JCI57132. Epub 2011 Jun 1.
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Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program.利用严重哮喘研究计划中的聚类分析鉴定哮喘表型。
Am J Respir Crit Care Med. 2010 Feb 15;181(4):315-23. doi: 10.1164/rccm.200906-0896OC. Epub 2009 Nov 5.