Han Yun, Rajah Gary B, Hussain Mohammed, Geng Xiaokun
a China-America Institute of Neuroscience, Beijing Luhe Hospital, Capital Medical University , Beijing , China.
b Department of Neurology, Beijing Luhe Hospital, Capital Medical University , Beijing , China.
Neurol Res. 2019 Aug;41(8):697-703. doi: 10.1080/01616412.2019.1609160. Epub 2019 Apr 28.
The damage caused by ischemic stroke is mostly refractory to medical therapies and amounts to a substantial degree of mortality and morbidity in the world. The core tenet of treatment for acute ischemic stroke (AIS) is to save 'reversible' ischemic tissue (ischemic penumbra) as quickly as possible within a limited therapeutic time window. The neuroprotective effect of hypothermia has been proven previously in a large number of animal experiments and clinical trials. Some of these animal and human studies have shown that pre-reperfusion hypothermia can reduce myocardial infarction and improve clinical outcomes. However, to date, there is little research about hypothermia before reperfusion in the animal model and human study of AIS. This review will explore possible benefits of the application of pre-reperfusion hypothermia in the setting of AIS.
缺血性中风造成的损害大多难以通过药物治疗治愈，在全球范围内导致了相当高的死亡率和发病率。急性缺血性中风（AIS）治疗的核心原则是在有限的治疗时间窗内尽快挽救“可逆性”缺血组织（缺血半暗带）。低温的神经保护作用此前已在大量动物实验和临床试验中得到证实。其中一些动物和人体研究表明，再灌注前低温可减少心肌梗死并改善临床结局。然而，迄今为止，在AIS的动物模型和人体研究中，关于再灌注前低温的研究很少。本综述将探讨在AIS情况下应用再灌注前低温可能带来的益处。
