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心肌梗死后合并与不合并糖尿病患者的心脏康复目标达标情况:一项全国登记研究。

Cardiac rehabilitation goal attainment after myocardial infarction with versus without diabetes: A nationwide registry study.

机构信息

Department of Women's and Children's Health, Uppsala University, Dag Hammarskjölds väg 14B, SE-75237 Uppsala, Sweden.

Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.

出版信息

Int J Cardiol. 2019 Oct 1;292:19-24. doi: 10.1016/j.ijcard.2019.04.049. Epub 2019 Apr 18.

Abstract

BACKGROUND

Patients with first-time myocardial infarction (MI) and diabetes mellitus (DM) constitute a vulnerable subgroup of cardiovascular (CV) patients for which secondary prevention is particularly important. We investigated if patients with versus without DM differ in attaining four main lifestyle-related cardiac rehabilitation (CR) targets, one-year post-MI.

METHODS

This national cohort study (2006-2015) identified individuals with and without DM at hospital admission in the Swedish cardiac registry, SWEDEHEART. CR goal attainment was assessed one year later. The study population included 47,907 unique patients with first-time MI <75 years at baseline (61.8 mean age, 26.7% women, 14.6% with DM). After imputation, propensity score matching was performed. Analyses were conducted with logistic regression.

RESULTS

In the matched population, having DM was associated (OR [95% CI]) with lower odds of attaining the one-year post-MI CR goal for both smoking cessation (0.90 [0.81, 0.99]) and attendance in exercise training (0.88 [0.83, 0.95]), yet with higher odds of the <1.8 mmol LDL-C target (1.28 [1.19, 1.36]), and similar odds for the <140 mm Hg systolic blood pressure target (0.97 [0.91, 1.04]). In addition, women with DM were particularly unlikely to attend exercise training.

CONCLUSIONS

Patients with first-time MI and DM are less likely to attain two of four selected CR goals compared to those without DM. The particularly low exercise training attendance by women with DM is of concern. Possibilities for tailored interventions targeting behavioural change for this high-risk group, including focused efforts to increase exercise training attendance in women with DM, should be investigated.

摘要

背景

首次心肌梗死(MI)和糖尿病(DM)患者构成了心血管(CV)患者的一个脆弱亚组,二级预防对他们尤为重要。我们研究了 MI 后一年,是否存在 DM 的患者在实现四项主要与生活方式相关的心脏康复(CR)目标方面存在差异。

方法

这项全国性队列研究(2006-2015 年)在瑞典心脏登记处 SWEDEHEART 中确定了入院时患有和不患有 DM 的个体。一年后评估 CR 目标的实现情况。研究人群包括 47907 名首次 MI 的独特患者,年龄均<75 岁(平均年龄 61.8 岁,26.7%为女性,14.6%患有 DM)。经过插补后,进行倾向评分匹配。分析采用 logistic 回归进行。

结果

在匹配人群中,患有 DM 与实现 MI 后一年 CR 目标的可能性较低相关(比值比[95%CI]),包括戒烟(0.90 [0.81, 0.99])和参加运动训练(0.88 [0.83, 0.95]),但更有可能达到<1.8mmol/L 的 LDL-C 目标(1.28 [1.19, 1.36]),并且达到<140mmHg 的收缩压目标的可能性相似(0.97 [0.91, 1.04])。此外,患有 DM 的女性特别不太可能参加运动训练。

结论

与不患有 DM 的患者相比,首次 MI 且患有 DM 的患者不太可能实现四项选定 CR 目标中的两项。患有 DM 的女性运动训练参与率特别低,令人担忧。应研究针对这一高危人群的行为改变的针对性干预措施的可能性,包括有针对性地努力增加患有 DM 的女性的运动训练参与率。

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