Singh A K, Vaughan-Smith S, Sawyer B, O'Connor T W, Thomson A E, Wetherley-Mein G
Br J Haematol. 1978 Dec;40(4):587-96. doi: 10.1111/j.1365-2141.1978.tb05835.x.
A case of prolymphocytic leukaemia, showing several features not yet reported in this disease, is reported. The majority of lymphocytes in the peripheral blood and bone marrow had markers of both B- and T-lymphocytes. The simultaneous presence of receptors for sheep RBC and surface immunoglobulins on individual cells was demonstrated and the endogenous origin of these markers was established. The lymphocytes had some of the functional characteristics seen in chronic lymphocytic leukaemia (CCL). In vitro cell death in the presence of colchicine (colchicine ultrasensitivity) and polystyrene bead column retention were of the same order as seen in CLL. In contrast with the findings in CLL, these cells were markedly radioresistant in vitro. The dominant clinical features--anaemia and constitutional symptoms--appeared to be related to hypersplenism associated with massive splenomegaly. The relevance of these findings is discussed.
本文报告了一例幼淋巴细胞白血病病例，该病例呈现出一些本病尚未报道过的特征。外周血和骨髓中的大多数淋巴细胞同时具有B淋巴细胞和T淋巴细胞的标志物。已证实单个细胞上同时存在绵羊红细胞受体和表面免疫球蛋白，且确定了这些标志物的内源性起源。这些淋巴细胞具有一些在慢性淋巴细胞白血病（CLL）中可见的功能特征。在秋水仙碱存在下的体外细胞死亡（秋水仙碱超敏感性）和聚苯乙烯珠柱滞留情况与CLL所见情况相当。与CLL的研究结果相反，这些细胞在体外具有明显的放射抗性。主要的临床特征——贫血和全身症状——似乎与伴有巨大脾肿大的脾功能亢进有关。文中讨论了这些发现的相关性。
