Mohsen Shorouk, Hanafy Fadia Zaki, Fathy Aya Ahmed, El-Gilany Abdel-Hady
Department of Public Health and Community Medicine, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Lung India. 2019 May-Jun;36(3):193-198. doi: 10.4103/lungindia.lungindia_340_18.
Chronic obstructive pulmonary disease (COPD) is one of the most common respiratory diseases. Assessment of medication nonadherence and quality of life (QOL) is important in such chronic diseases. The aim of the study was to describe treatment nonadherence and QOL of COPD patients and their associated factors.
A cross-sectional study was performed in Mansoura Chest Hospital on 133 already diagnosed inpatient cases of COPD from March to August 2017. Data were collected using two validated questionnaires, Morisky Medication Adherence Scale to assess medication adherence and St George's Respiratory Questionnaire for COPD patients (SGRQ-c) to assess QOL.
About 45% of studied group were nonadherent to prescribed medications. Logistic regression analysis showed that duration of disease is the only independent risk factor for nonadherence. The scores on SGRQ-c indicated sever QOL affection in COPD. SGRQ-c scores show significant impairment with the presence of comorbidities, hospital admission, and frequency of exacerbations.
Nonadherence to treatment was affected mainly by the duration of disease. QOL impairment in COPD is influenced by broad range of factors suggesting the importance of QOL assessment in those patients. No association was found between nonadherence to treatment and QOL.
慢性阻塞性肺疾病（COPD）是最常见的呼吸系统疾病之一。在这类慢性疾病中，评估药物治疗依从性和生活质量（QOL）很重要。本研究的目的是描述COPD患者的治疗依从性和生活质量及其相关因素。
2017年3月至8月，在曼苏拉胸科医院对133例已确诊的COPD住院患者进行了一项横断面研究。使用两份经过验证的问卷收集数据，即用于评估药物治疗依从性的Morisky药物治疗依从性量表和用于评估COPD患者生活质量的圣乔治呼吸问卷（SGRQ-c）。
研究组中约45%的患者未坚持按规定用药。逻辑回归分析表明，疾病持续时间是不依从的唯一独立危险因素。SGRQ-c评分表明COPD患者的生活质量受到严重影响。SGRQ-c评分在合并症、住院和病情加重频率存在时显示出显著损害。
治疗不依从主要受疾病持续时间的影响。COPD患者的生活质量损害受多种因素影响，这表明对这些患者进行生活质量评估很重要。未发现治疗不依从与生活质量之间存在关联。
