Moradkhani Boyuk, Mollazadeh Samaneh, Niloofar Parastoo, Bashiri Afsaneh, Oghazian Mohammad Bagher
Clinical Research Development Unit, Imam Hasan Hospital, North Khorasan University of Medical Sciences, Bojnurd, Iran.
Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran.
J Pharm Health Care Sci. 2021 Nov 15;7(1):40. doi: 10.1186/s40780-021-00222-x.
Chronic Obstructive Pulmonary Disease (COPD) is one of the prominent cause of mortality worldwide. Nowadays, the level of medication adherence in COPD patients is very low, which reduces the clinical therapeutic effects. The purpose of the present study is to investigate the relationship between medication adherence and Health-Related Quality of Life (HRQoL) in COPD patients referred to the pulmonologist's office.
This observational study was performed on 100 COPD outpatient cases. Each patient was interviewed to answer questionnaires regarding demographic and clinical information. To assess quality of life, health status, and severity of dyspnea, the St George's Respiratory Questionnaire - COPD-Specific Version (SGRQ-C), COPD Assessment Test (CAT), and Modified British Medical Research Council (mMRC) questionnaires were used, respectively. Persian version of the Morisky Medication Adherence Scale (MMAS-8-Item) was used to measure medication adherence. To determine the adherence predictors, an ordinal logistic regression analysis was performed.
Out of 100 patients with mean (±SD) age of 61.35 (±10.79) years, 74% had medium and high medication adherence. In the final ordinal logistic model, quality of life, health status, and education level found to have positive effect on medication adherence while polypharmacy had negative effect. We did not find any significant association between age, gender, Body Mass Index (BMI), and other variables with medication adherence.
Patients with high quality of life are more adherent to their medications. Furthermore, patients who have polypharmacy, tend to have less adherence to their medications.
慢性阻塞性肺疾病（COPD）是全球范围内主要的死亡原因之一。如今，COPD患者的药物依从性水平非常低，这降低了临床治疗效果。本研究的目的是调查转诊至肺科医生办公室的COPD患者的药物依从性与健康相关生活质量（HRQoL）之间的关系。
本观察性研究对100例COPD门诊病例进行。对每位患者进行访谈，以回答有关人口统计学和临床信息的问卷。分别使用圣乔治呼吸问卷-COPD特定版本（SGRQ-C）、COPD评估测试（CAT）和改良英国医学研究委员会（mMRC）问卷来评估生活质量、健康状况和呼吸困难严重程度。使用波斯语版的Morisky药物依从性量表（MMAS-8项）来测量药物依从性。为了确定依从性预测因素，进行了有序逻辑回归分析。
100例患者的平均（±标准差）年龄为61.35（±10.79）岁，其中74%的患者药物依从性为中高。在最终的有序逻辑模型中，生活质量、健康状况和教育水平对药物依从性有积极影响，而联合用药有负面影响。我们未发现年龄、性别、体重指数（BMI）和其他变量与药物依从性之间存在任何显著关联。
生活质量高的患者对药物的依从性更高。此外，联合用药的患者往往对药物的依从性较低。
