Zahn T P, Rapoport J L
Psychopharmacology (Berl). 1987;91(1):40-4. doi: 10.1007/BF00690924.
The effects of caffeine on autonomic activity were tested in 19 normal prepubertal boys. Subjects received placebo, 3 mg/kg, and 10 mg/kg caffeine in a random order (double blind) before three test sessions 48 h apart. Skin conductance (SC), heart rate (HR), and skin temperature (ST) were recorded during a rest period, a series of nonsignal tones, and a simple reaction time (RT) task. Caffeine increased the frequency of both spontaneous and elicited SC responses (SCR) under all conditions. Resting SC base level (SCL) was increased, and shorter SCR half recovery time also occurred in some periods. In contrast, caffeine decreased HR and motor activity at 3 mg/kg. Evidence of improved attention on caffeine was also obtained. The physiological effects are partially similar to the effects seen in clinical anxiety states, and they are also consistent with the physiological concomitants of good sustained attention. The profile of effects did not resemble those of dextroamphetamine in a similar population.
在19名青春期前的正常男孩中测试了咖啡因对自主神经活动的影响。在相隔48小时的三个测试时段之前，受试者以随机顺序（双盲）接受安慰剂、3毫克/千克和10毫克/千克的咖啡因。在休息期、一系列无信号音调以及简单反应时间（RT）任务期间记录皮肤电导率（SC）、心率（HR）和皮肤温度（ST）。在所有条件下，咖啡因均增加了自发和诱发的皮肤电反应（SCR）的频率。静息皮肤电导基线水平（SCL）升高，并且在某些时段也出现了较短的SCR半恢复时间。相比之下，3毫克/千克的咖啡因降低了心率和运动活动。还获得了咖啡因能改善注意力的证据。其生理效应部分类似于临床焦虑状态下所见的效应，并且也与良好持续注意力的生理伴随现象一致。在类似人群中，其效应模式与右旋苯丙胺不同。
