Fang Meidan, Zhong Lili, Jin Xin, Cui Ranji, Yang Wei, Gao Shuohui, Lv Jing, Li Bingjin, Liu Tongjun
Department of General Surgery, Second Hospital of Jilin University, Changchun, China.
Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, Second Hospital of Jilin University, Changchun, China.
Front Psychiatry. 2019 Apr 11;10:184. doi: 10.3389/fpsyt.2019.00184. eCollection 2019.
A considerable body of evidence has shown that inflammation plays an important role in the process of stroke rehabilitation and development of poststroke depression (PSD). However, the specific molecular and cellular mechanisms involved remain unclear. In this review, we summarize how neuroinflammation affects stroke rehabilitation and PSD. We mainly focus on the immune/inflammatory response, involving astrocytes, microglia, monocyte-derived macrophages, cytokines (tumor necrosis factor alpha, interleukin 1), and microRNAs (microRNA-124, microRNA 133b). This review provides new insights into the effect of inflammation on the process of stroke rehabilitation and PSD and potentially offer new therapeutic targets of stroke and PSD.
大量证据表明，炎症在中风康复及中风后抑郁症（PSD）的发生过程中起着重要作用。然而，其中具体涉及的分子和细胞机制仍不清楚。在本综述中，我们总结了神经炎症如何影响中风康复和PSD。我们主要关注免疫/炎症反应，涉及星形胶质细胞、小胶质细胞、单核细胞衍生的巨噬细胞、细胞因子（肿瘤坏死因子α、白细胞介素1）和微小RNA（微小RNA-124、微小RNA 133b）。本综述为炎症对中风康复和PSD过程的影响提供了新见解，并可能为中风和PSD提供新的治疗靶点。
