Lassi G, Taylor A E, Mahedy L, Heron J, Eisen T, Munafò M R
MRC Integrative Epidemiology Unit (IEU) at the University of Bristol, Bristol, UK.
Centre for Genomics Research, Precision Medicine and Genomics, IMED Biotech Unit, AstraZeneca, Cambridge, UK.
R Soc Open Sci. 2019 Mar 27;6(3):181133. doi: 10.1098/rsos.181133. eCollection 2019 Mar.
Individuals appraise events as a consequence of their own actions (i.e. internal locus of control, LoC) or as the outcome of chance or others' will (i.e. external LoC). We hypothesized that having a more external LoC would be associated with higher risk of tobacco and alcohol use. Few studies have examined this association using large prospective data. We evaluated within the Avon Longitudinal Study of Parents and Children (ALSPAC) the associations between LoC at 16 and tobacco and alcohol consumption at 17 and 21 years using logistic regression. A more external LoC at age 16 ( = 4656) was associated with higher odds of being a weekly smoker at age 17 (OR 1.18, 95% CI 1.10-1.25) and 21 (OR 1.14, 95% CI 1.07-1.21) and with dependence measured using the Fagerström Test of Nicotine Dependence at age 17 (OR 1.26, 95% CI 1.05-1.51) and 21 (OR 1.25, 95% CI 1.05-1.49). Individuals with external LoC at age 16 were more likely to be hazardous drinkers according to the Alcohol Use Disorders Identification Test at age 17 (OR 1.09, 95% CI 1.04-1.15) but not at 21 (OR 1.01, 95% CI 0.96-1.06). Having a more external LoC at age 16 is associated with increased tobacco consumption at age 17 and 21 and alcohol consumption at 17 years. LoC may represent an intervention target for preventing substance use and dependence.
个体将事件评估为自身行为的结果(即内控点,LoC),或评估为机遇或他人意志的结果(即外控点)。我们假设,外控点程度越高,烟草和酒精使用风险越高。很少有研究使用大型前瞻性数据来检验这种关联。我们在阿冯父母与儿童纵向研究(ALSPAC)中,采用逻辑回归评估了16岁时的内控点与17岁和21岁时的烟草及酒精消费之间的关联。16岁时外控点程度更高(n = 4656)与17岁(比值比1.18,95%置信区间1.10 - 1.25)和21岁(比值比1.14,95%置信区间1.07 - 1.21)成为每周吸烟者的较高几率相关,并且与17岁(比值比1.26,95%置信区间1.05 - 1.51)和21岁(比值比1.25,95%置信区间1.05 - 1.49)使用尼古丁依赖的法格斯特龙测试测量的依赖程度相关。根据17岁时的酒精使用障碍识别测试,16岁时具有外控点的个体更有可能成为危险饮酒者(比值比1.09,95%置信区间1.04 - 1.15),但在21岁时并非如此(比值比1.01,95%置信区间0.96 - 1.06)。16岁时外控点程度更高与17岁和21岁时烟草消费增加以及17岁时酒精消费增加相关。内控点可能是预防物质使用和依赖的一个干预靶点。