Department of Physiopathology, Medical University of Gdańsk, Dębinki 7, 80-210, Gdańsk, Poland.
Department of Adult Psychiatry, Medical University of Gdańsk, Gdańsk, Poland.
Arch Immunol Ther Exp (Warsz). 2019 Jun;67(3):143-151. doi: 10.1007/s00005-019-00543-8. Epub 2019 Apr 29.
Depression is one of the most frequently diagnosed condition in psychiatry. Despite the availability of many preparations, over 30% of treated patients do not achieve remission. Recently the emphasis is put on the contribution of the body's inflammatory response as one of the causes of depression. The interactions between nervous and immune systems are the main issue addressed by psychoneuroimmunology. In patients suffering from depression changes in the plasma concentrations of cytokines and in the number and level of activation of immune cells has been found. Attention is paid to the high levels of pro-inflammatory cytokines, the prevalence of Th1 responses to Th2, weakening of NK cell cytotoxicity and changes in lymphocyte proliferation and apoptosis. A number of studies focus on influence of antidepressants and non-standard methods of depression treatment, such as ketamine infusion, on patients' immunology. Many of them seem to regulate the immune responses. The study results encourage to look for new ways to treat depression with immunomodulatory drugs. In this article authors present the current knowledge about immune system changes accompanying depression as well as the study results showing the influence of drugs on the immune system, especially in the context of reducing the symptoms of depression.
抑郁症是精神病学中最常见的诊断疾病之一。尽管有许多制剂可用，但超过 30%的接受治疗的患者并未缓解。最近，人们越来越关注身体炎症反应作为抑郁症病因之一的贡献。神经和免疫系统之间的相互作用是心理神经免疫学所关注的主要问题。在抑郁症患者中，已经发现细胞因子的血浆浓度以及免疫细胞的数量和激活水平发生了变化。人们关注促炎细胞因子的高水平、Th1 对 Th2 的反应流行、NK 细胞细胞毒性减弱以及淋巴细胞增殖和凋亡的变化。许多研究都集中在抗抑郁药和非标准的抑郁症治疗方法（如氯胺酮输注）对患者免疫的影响上。其中许多似乎调节了免疫反应。研究结果鼓励寻找新的方法，用免疫调节药物治疗抑郁症。本文作者介绍了伴随抑郁症的免疫系统变化的现有知识，以及研究结果表明药物对免疫系统的影响，特别是在减轻抑郁症症状方面。
