Voormolen Daphne C, Cnossen Maryse C, Polinder Suzanne, Gravesteijn Benjamin Y, Von Steinbuechel Nicole, Real Ruben G L, Haagsma Juanita A
a Department of Public Health , Erasmus University Medical Centre Rotterdam , Rotterdam , the Netherlands.
b Institute of Medical Psychology and Medical Sociology , Georg-August-University , Göttingen , Germany.
Brain Inj. 2019;33(8):1078-1086. doi: 10.1080/02699052.2019.1607557. Epub 2019 Apr 29.
: To evaluate the frequency of post-concussion symptoms and prevalence and risk factors of post-concussion syndrome (PCS) in the general population, investigate the association between the Rivermead Post-Concussion Symptoms Questionnaire (RPQ) and self-perceived health, and evaluate differences between three European countries. : A web-based survey including the RPQ and EQ-5D was conducted among representative samples in three European countries. : A total of 11,759 respondents completed the questionnaire. The most frequently reported symptom was fatigue (49.9%). Almost half (45.1%) of the respondents were classified as having PCS considering rating score 2 (three RPQ items with score ≥ 2) as a cut-off. Chronic health complaints were found as a significant risk factor for PCS. All items of the RPQ were positively correlated with the EQ-5D and the strongest positive correlation (0.633, p<0.001) was between RPQ item 'feeling depressed or tearful' and EQ-5D domain 'anxiety/depression'. : We found a high frequency of post-concussion-like symptoms and PCS in the general population, indicating that these symptoms are not specific for patients with traumatic brain injury (TBI), and PCS is not a unique syndrome after TBI. Therefore, the use of post-concussion symptoms and PCS as outcome following mild TBI should be interpreted with caution.
为评估普通人群中脑震荡后症状的发生频率、脑震荡后综合征（PCS）的患病率及危险因素，研究Rivermead脑震荡后症状问卷（RPQ）与自我感知健康之间的关联，并评估三个欧洲国家之间的差异。：在三个欧洲国家的代表性样本中开展了一项包含RPQ和EQ-5D的网络调查。：共有11759名受访者完成了问卷。最常报告的症状是疲劳（49.9%）。将评分2（RPQ中三项得分≥2）作为临界值时，近一半（45.1%）的受访者被归类为患有PCS。慢性健康问题被发现是PCS的一个显著危险因素。RPQ的所有项目均与EQ-5D呈正相关，且最强的正相关（0.633，p<0.001）存在于RPQ项目“感到抑郁或流泪”与EQ-5D领域“焦虑/抑郁”之间。：我们发现普通人群中脑震荡样症状和PCS的发生频率较高，这表明这些症状并非创伤性脑损伤（TBI）患者所特有，且PCS也不是TBI后的独特综合征。因此，在轻度TBI后将脑震荡后症状和PCS用作结局指标时应谨慎解读。
