a Department of Biochemistry , National JALMA Institute for Leprosy & Other Mycobacterial Diseases (ICMR) , Agra , India.
b Medical Microbiology and Molecular Biology Laboratory , Interdisciplinary Biotechnology Unit, Aligarh Muslim University , Aligarh , India.
Expert Rev Proteomics. 2019 May;16(5):443-456. doi: 10.1080/14789450.2019.1608185. Epub 2019 Apr 27.
This review aimed at providing an update on the application of proteomics-based approaches to gain recent insights of Mycobacterium tuberculosis (M.tb) and its relevance to clinic. Proteomics and bioinformatics approaches helped in the identification and characterization of novel proteins. Studying M.tb, causative agent of tuberculosis (TB), at the proteomic level can contribute to the identification of proteins which can be considered as potential targets for developed drugs and can help us in better understanding the pathogen physiology. Areas covered: In this review we have presented a comprehensive literature pertaining to role of proteomics in understanding M.tb. We have also focused on how the development and advancement in technology in the field of proteomics has augmented the research and played a pivotal role in answering many unexplored questions. Lastly, the application of proteomics to clinic has also been discussed. Expert commentary: We envisage that proteomics has gained remarkable momentum over the years. Proteomics can play an important role in the discovery of biomarkers for TB and other diseases. Also, it can aid in development of effective vaccines and simple, rapid and cost-effective test for the diagnosis of TB which is crucial for the management and control of the disease.
本综述旨在提供基于蛋白质组学方法的最新应用，以深入了解结核分枝杆菌（M.tb）及其与临床的相关性。蛋白质组学和生物信息学方法有助于鉴定和描述新的蛋白质。在蛋白质组学水平上研究结核分枝杆菌（导致结核病的病原体）可以有助于鉴定可以被认为是潜在药物靶点的蛋白质，并帮助我们更好地了解病原体的生理学。涵盖领域：在本综述中，我们提出了一份关于蛋白质组学在理解 M.tb 中的作用的综合文献。我们还重点介绍了技术在蛋白质组学领域的发展和进步如何增强了研究，并在回答许多未探索的问题方面发挥了关键作用。最后，还讨论了蛋白质组学在临床中的应用。专家评论：我们预计，蛋白质组学多年来已经取得了显著的进展。蛋白质组学可以在结核病和其他疾病的生物标志物发现中发挥重要作用。此外，它可以帮助开发有效的疫苗，并为结核病的诊断提供简单、快速和具有成本效益的测试，这对于疾病的管理和控制至关重要。
