Zhang Li-Ping, Zhang Lu, Wang Guanqun, Adhikari Binay Kumar, Liu Quan, Zhang Weihua
1 Clinical Laboratory of Cardiovascular Centre, the First Hospital of Jilin University, Changchun, China.
These authors contributed equally to this work.
J Int Med Res. 2019 Jun;47(6):2716-2722. doi: 10.1177/0300060519843734. Epub 2019 Apr 28.
Solitary fibrous tumours are unusual neoplasms that develop from mesenchymal cells, usually originating from the pleura. A pericardial solitary fibrous tumour is an extremely rare occurrence. We report a 64-year-old woman who presented to the hospital with chief complaints of dyspnoea and abdominal distension. Echocardiography and enhanced computed tomography revealed an intrapericardial tumour with local invasion to the right atrium. Histopathological examination of a biopsy specimen showed a patternless distribution of spindle-shaped cells in a collagen stroma, with a high mitosis rate. Immunohistochemistry was positive for vimentin, CD34, and Bcl-2. The final diagnosis was a pericardial malignant solitary fibrous tumour with right atrial invasion. Surgical resection of the tumour was not performed because of its invasion into the myocardium. We systematically reviewed the literature on cardiac solitary fibrous tumours up to 2019.
孤立性纤维瘤是一种罕见的肿瘤，由间充质细胞发展而来，通常起源于胸膜。心包孤立性纤维瘤极为罕见。我们报告一例64岁女性，因呼吸困难和腹胀为主诉入院。超声心动图和增强计算机断层扫描显示心包内肿瘤并局部侵犯右心房。活检标本的组织病理学检查显示在胶原基质中梭形细胞呈无规律分布，有较高的有丝分裂率。免疫组织化学检查波形蛋白、CD34和Bcl-2呈阳性。最终诊断为心包恶性孤立性纤维瘤伴右心房侵犯。由于肿瘤侵犯心肌，未进行手术切除。我们系统回顾了截至2019年关于心脏孤立性纤维瘤的文献。
