新生儿腹膜透析期间腹腔内万古霉素应用：病例报告。
Intraperitoneal vancomycin in neonates during peritoneal dialysis: A case report.
机构信息
Pharmacy Department, Health Research Institute La Fe (IIS La Fe), Hospital Universitario y Politécnico La Fe, Valencia, Spain.
Neonatal Research Group, Health Research Institute La Fe (IIS La Fe), Hospital Universitario y Politécnico La Fe, Valencia, Spain.
出版信息
J Clin Pharm Ther. 2019 Aug;44(4):647-649. doi: 10.1111/jcpt.12842. Epub 2019 Apr 29.
WHAT IS KNOWN AND OBJECTIVE
Guidelines for prevention and treatment of peritonitis in paediatric patients recommend vancomycin. We present the clinical practice in neonates during peritoneal dialysis and evaluate dosage and serum levels of vancomycin.
CASE SUMMARY
This case report describes a newborn with acute renal failure under continuous peritoneal dialysis therapy and intraperitoneal vancomycin. We report the treatment dosage and serum vancomycin levels.
WHAT IS NEW AND CONCLUSION
There is great variability in the recommended dose of vancomycin for continuous peritoneal dialysis and the available clinical experience. Further investigation of dosing in children particularly in newborns, especially in loading dose, is necessary.
已知和目的
小儿患者腹膜炎预防和治疗指南推荐使用万古霉素。我们介绍了新生儿腹膜透析时的临床实践，并评估了万古霉素的剂量和血清水平。
病例总结
本病例报告描述了一例急性肾功能衰竭新生儿接受持续腹膜透析治疗和腹腔内万古霉素治疗的情况。我们报告了治疗剂量和血清万古霉素水平。
创新和结论
连续腹膜透析中万古霉素推荐剂量和现有临床经验差异很大。需要进一步研究儿童，特别是新生儿，特别是在负荷剂量时的给药剂量。
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