Division of Dermatology, Women's College Hospital, Toronto, Ontario, Canada.
Cosmetic Dermatology, Yorkville, Ontario, Canada.
J Cosmet Dermatol. 2019 Jun;18(3):738-746. doi: 10.1111/jocd.12961. Epub 2019 Apr 29.
Subjects seeking facial rejuvenation want the results to appear natural. Currently, however, there is no consensus definition of, or assessment scale for, "naturalness."
This open-label pilot study explored evaluation techniques and criteria to assess naturalness of facial movement and expression following optimal bilateral correction of moderate-to-severe nasolabial folds and marionette lines with soft-tissue hyaluronic acid fillers formulated with XpresHAn Technology™.
Primary efficacy was investigator assessed naturalness of dynamic expressions using baseline and Day 42 posttreatment 2D video. Other evaluations included investigator assessed naturalness using static images, wrinkle severity, investigator and subject Global Aesthetic Improvement Scale assessments, and subject satisfaction.
Thirty Caucasian females (41-65 years) received either Restylane Refyne, Restylane Defyne or both. Naturalness of dynamic expressions was at least maintained in all subjects. Naturalness of static expressions was not negatively affected in most subjects (96.7%). For dynamic expressions, 83.3% of subjects showed enhanced attractiveness, younger appearance and maintained naturalness.
Overall, nasolabial folds and marionette lines improved significantly based on severity and Global Aesthetic Improvement Scale scores, with high subject satisfaction and favorable safety profile. Based on subject satisfaction and investigator assessments, using highly flexible hyaluronic acid dermal fillers did not compromise naturalness of lower facial expressions while achieving the desired improvements in attractiveness and youthfulness. The preliminary results obtained in this pilot study suggest that dynamic and static assessments of facial animation may aid the evaluation of natural outcomes in facial rejuvenation procedures.
寻求面部年轻化的患者希望治疗效果自然。然而，目前对于“自然度”尚没有共识的定义或评估标准。
本开放性标签的初步研究旨在探索评估技术和标准，以评估经优化的双侧治疗后，中度至重度鼻唇沟和木偶纹采用含 XpresHAn 技术的透明质酸软组织填充剂治疗后的面部运动和表情的自然度。
主要疗效指标为研究者采用基线和治疗后 42 天的 2D 视频评估动态表情的自然度。其他评估包括：研究者采用静态图像评估自然度，皱纹严重程度，研究者和患者的整体美学改善量表评估以及患者满意度。
30 名高加索女性（41-65 岁）接受了瑞蓝·瑞瑅、瑞蓝·唯瑅或两者的联合治疗。所有患者的动态表情自然度至少保持不变。大多数患者（96.7%）的静态表情自然度不受影响。在动态表情方面，83.3%的患者表现出更吸引人、更年轻的外观和保持自然度。
鼻唇沟和木偶纹的严重程度和整体美学改善量表评分均显著改善，患者满意度高，安全性良好。基于患者满意度和研究者评估，使用高柔顺性的透明质酸真皮填充剂不会影响下面部表情的自然度，同时可实现对吸引力和年轻度的预期改善。本初步研究的初步结果表明，对面部动画的动态和静态评估可能有助于评估面部年轻化治疗的自然结果。
