Department of Chemical Engineering , Imperial College London , London SW7 2AZ , United Kingdom.
Department of Chemistry , Ecole Normale Superieure , 75005 Paris , France.
Langmuir. 2019 Aug 6;35(31):10087-10096. doi: 10.1021/acs.langmuir.8b04008. Epub 2019 Apr 29.
Biomedical microbubbles stabilized by a coating of magnetic or drug-containing nanoparticles show great potential for theranostics applications. Nanoparticle-coated microbubbles can be made to be stable, to be echogenic, and to release the cargo of drug-containing nanoparticles with an ultrasound trigger. This Article reviews the design principles of nanoparticle-coated microbubbles for ultrasound imaging and drug delivery, with a particular focus on the physical chemistry of nanoparticle-coated interfaces; the formation, stability, and dynamics of nanoparticle-coated bubbles; and the conditions for controlled nanoparticle release in ultrasound. The emerging understanding of the modes of nanoparticle expulsion and of the transport of expelled material by microbubble-induced flow is paving the way toward more efficient nanoparticle-mediated drug delivery. This Article highlights the knowledge gap that still remains to be addressed before we can control these phenomena.
由磁或含药纳米颗粒涂层稳定的生物医学微泡在治疗诊断应用中具有巨大潜力。可以使纳米颗粒涂层微泡稳定、具有声反射性，并在超声触发下释放含药纳米颗粒的货物。本文综述了用于超声成像和药物输送的纳米颗粒涂层微泡的设计原理，特别关注纳米颗粒涂层界面的物理化学；纳米颗粒涂层气泡的形成、稳定性和动力学；以及在超声下控制纳米颗粒释放的条件。对纳米颗粒排出的模式和微泡诱导流中排出物质的传输的新理解，为更有效的纳米颗粒介导的药物输送铺平了道路。本文强调了在我们能够控制这些现象之前仍然存在的知识差距。
