军人 Tau 蛋白升高与创伤性脑损伤后慢性症状有关。
Elevated Tau in Military Personnel Relates to Chronic Symptoms Following Traumatic Brain Injury.
机构信息
National Institute of Nursing Research, National Institutes of Health, Bethesda, Maryland (Drs Pattinson, Guedes, Lai, and Gill, Ms Motamedi, and Messrs Devoto and Peyer); Center for Neuroscience and Regenerative Medicine, Rockville, Maryland (Dr Shahim and Mss Taylor and Dunbar); National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland (Dr Shahim); Henry M. Jackson Foundation, Bethesda, Maryland (Mss Taylor and Dunbar and Dr Roy); and Uniformed Services University of the Health Sciences, Department of Medicine, Bethesda, Maryland (Dr Roy).
出版信息
J Head Trauma Rehabil. 2020 Jan/Feb;35(1):66-73. doi: 10.1097/HTR.0000000000000485.
OBJECTIVE
To understand the relationships between traumatic brain injury (TBI), blood biomarkers, and symptoms of posttraumatic stress disorder (PTSD), depression, and postconcussive syndrome symptoms.
DESIGN
Cross-sectional cohort study using multivariate analyses.
PARTICIPANTS
One hundred nine military personnel and veterans, both with and without a history of TBI.
MAIN MEASURES
PTSD Checklist-Civilian Version (PCL-C); Neurobehavioral Symptom Inventory (NSI); Ohio State University TBI Identification Method; Patient Health Questionnaire-9 (PHQ-9); Simoa-measured concentrations of tau, amyloid-beta (Aβ) 40, Aβ42, and neurofilament light (NFL).
RESULTS
Controlling for age, sex, time since last injury (TSLI), and antianxiety/depression medication use, NFL was trending toward being significantly elevated in participants who had sustained 3 or more TBIs compared with those who had sustained 1 or 2 TBIs. Within the TBI group, partial correlations that controlled for age, sex, TSLI, and antianxiety/depression medication use showed that tau concentrations were significantly correlated with greater symptom severity, as measured with the NSI, PCL, and PHQ-9.
CONCLUSIONS
Elevations in tau are associated with symptom severity after TBI, while NFL levels are elevated in those with a history of repetitive TBIs and in military personnel and veterans. This study shows the utility of measuring biomarkers chronically postinjury. Furthermore, there is a critical need for studies of biomarkers longitudinally following TBI.
目的
了解创伤性脑损伤（TBI）、血液生物标志物与创伤后应激障碍（PTSD）、抑郁和脑震荡后综合征症状之间的关系。
设计
使用多变量分析的横断面队列研究。
参与者
109 名军人和退伍军人，包括有和无 TBI 病史者。
主要测量指标
平民版 PTSD 检查表（PCL-C）；神经行为症状量表（NSI）；俄亥俄州立大学 TBI 识别方法；患者健康问卷-9（PHQ-9）；Simoa 测量的 tau、淀粉样蛋白-β（Aβ）40、Aβ42 和神经丝轻链（NFL）浓度。
结果
控制年龄、性别、末次损伤后时间（TSLI）和抗焦虑/抑郁药物使用情况，与 1 或 2 次 TBI 相比，3 次或以上 TBI 患者的 NFL 呈显著升高趋势。在 TBI 组中，控制年龄、性别、TSLI 和抗焦虑/抑郁药物使用情况的部分相关分析显示，tau 浓度与 NSI、PCL 和 PHQ-9 测量的症状严重程度显著相关。
结论
tau 的升高与 TBI 后的症状严重程度相关，而 NFL 水平在有重复 TBI 病史者以及军人和退伍军人中升高。本研究表明了在损伤后慢性测量生物标志物的效用。此外，需要对 TBI 后进行生物标志物的纵向研究。
Zotero 插件