Akiki Teddy J, Averill Christopher L, Abdallah Chadi G
Clinical Neuroscience Division-National Center for PTSD, VA Connecticut Healthcare System, 950 Campbell Avenue, 151E, West Haven, CT, 06516, USA.
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Curr Psychiatry Rep. 2017 Sep 19;19(11):81. doi: 10.1007/s11920-017-0840-4.
Although a fine-grained understanding of the neurobiology of posttraumatic stress disorder (PTSD) is yet to be elucidated, the last two decades have seen a rapid growth in the study of PTSD using neuroimaging techniques. The current review summarizes important findings from functional and structural neuroimaging studies of PTSD, by primarily focusing on their relevance towards an emerging network-based neurobiological model of the disorder.
PTSD may be characterized by a weakly connected and hypoactive default mode network (DMN) and central executive network (CEN) that are putatively destabilized by an overactive and hyperconnected salience network (SN), which appears to have a low threshold for perceived saliency, and inefficient DMN-CEN modulation. There is considerable evidence for large-scale functional and structural network dysfunction in PTSD. Nevertheless, several limitations and gaps in the literature need to be addressed in future research.
尽管对创伤后应激障碍（PTSD）神经生物学的细粒度理解尚待阐明，但在过去二十年中，使用神经成像技术对PTSD的研究迅速增长。本综述总结了PTSD功能和结构神经成像研究的重要发现，主要关注它们与该疾病新兴的基于网络的神经生物学模型的相关性。
PTSD的特征可能是默认模式网络（DMN）和中央执行网络（CEN）连接薄弱且活动不足，这两个网络可能因显著网络（SN）过度活跃和连接过度而不稳定，而显著网络似乎对感知显著性的阈值较低，并且DMN-CEN调制效率低下。有大量证据表明PTSD存在大规模功能和结构网络功能障碍。然而，文献中的几个局限性和空白需要在未来的研究中加以解决。
