舒马曲坦-萘普生对炎症性头痛模型中脑网络的调节作用。
Modulation of brain networks by sumatriptan-naproxen in the inflammatory soup migraine model.
机构信息
Department of Anesthesia, Pain/Analgesia Imaging Neuroscience (PAIN) Group, Center for Pain and the Brain, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.
Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States.
出版信息
Pain. 2019 Sep;160(9):2161-2171. doi: 10.1097/j.pain.0000000000001583.
Migraine is a debilitating condition; however, the pharmacological effects on central nervous system networks after successful therapy are poorly understood. Defining this neurocircuitry is critical to our understanding of the disorder and for the development of antimigraine drugs. Using an established inflammatory soup model of migraine-like pathophysiology (N = 12) compared with sham synthetic interstitial fluid migraine induction (N = 12), our aim was to evaluate changes in network-level functional connectivity after sumatriptan-naproxen infusion in awake, conscious rodents (Sprague-Dawley rats). Sumatriptan-naproxen infusion functional magnetic resonance imaging data were analyzed using an independent component analysis approach. Whole-brain analysis yielded significant between-group (inflammatory soup vs synthetic interstitial fluid) alterations in functional connectivity across the cerebellar, default mode, basal ganglia, autonomic, and salience networks. These results demonstrate the large-scale antimigraine effects of sumatriptan-naproxen co-administration after dural sensitization.
偏头痛是一种使人虚弱的疾病；然而，成功治疗后对中枢神经系统网络的药物作用仍知之甚少。明确这一神经回路对于我们理解这种疾病以及开发抗偏头痛药物至关重要。我们使用已建立的偏头痛样病理生理学炎症汤模型（N = 12）与假合成细胞间液偏头痛诱导（N = 12）进行比较，旨在评估清醒、有意识的啮齿动物（斯普拉格-道利大鼠）中舒马曲坦-萘普生输注后网络级功能连接的变化。使用独立成分分析方法对舒马曲坦-萘普生输注功能磁共振成像数据进行了分析。全脑分析显示，在小脑、默认模式、基底神经节、自主和显着网络中，炎症汤组与合成细胞间液组之间存在功能连接的显著组间变化。这些结果表明，舒马曲坦-萘普生联合给药在硬脑膜致敏后具有广泛的抗偏头痛作用。
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