Castillo-Duran C, Heresi G, Fisberg M, Uauy R
Am J Clin Nutr. 1987 Mar;45(3):602-8. doi: 10.1093/ajcn/45.3.602.
To evaluate the effect of zinc on growth and immune function, 32 marasmic infants were selected on admission to the nutrition recovery center; 16 received 2 mg/kg daily of elemental zinc supplement as acetate and the remaining received a placebo. Immunity was assessed by skin-test response, T-cell blastic proliferation immunoglobulins, and infectious morbidity. Weight-for-length gain for initial 60 days in Zn-supplemented group was 9% of standard vs 3% for placebo (p less than 0.05). Energy intake was similar in both groups. Incidence of infections, especially pyoderma, was significantly higher in placebo group: 10 of 16 vs 3 of 16 in the supplemented group (p less than 0.025). Plasma Zn was correlated with number of febrile days in the prospective month (r = -0.66, p less than 0.05). The percent anergic infants decreased and serum IgA increased significantly only in Zn-supplemented group. Zinc supplementation has significant effects on weight gain and host defense mechanisms despite normal plasma levels. Zinc supplementation is recommended for optimal recovery from marasmus.
为评估锌对生长及免疫功能的影响，32名消瘦婴儿在进入营养康复中心时被选中；16名婴儿每日接受2毫克/千克元素锌补充剂醋酸锌，其余婴儿接受安慰剂。通过皮肤试验反应、T细胞母细胞增殖免疫球蛋白及感染发病率评估免疫功能。补充锌组最初60天的身长体重增加为标准值的9%，而安慰剂组为3%（p小于0.05）。两组的能量摄入相似。安慰剂组感染发生率，尤其是脓疱病发生率显著更高：16名中有10名，而补充锌组16名中有3名（p小于0.025）。血浆锌与前一个月发热天数相关（r = -0.66，p小于0.05）。仅在补充锌组无反应性婴儿百分比下降且血清IgA显著增加。尽管血浆锌水平正常，但补充锌对体重增加及宿主防御机制有显著影响。建议补充锌以实现消瘦的最佳康复。
