Schneider Tobias, Caviezel Daniel, Ayata C Korcan, Kiss Caroline, Niess Jan Hendrik, Hruz Petr
Department of Gastroenterology and Hepatology, Clarunis, Basel, Switzerland.
Department of Biomedicine, University of Basel, Basel, Switzerland.
Crohns Colitis 360. 2020 Jan;2(1):otaa001. doi: 10.1093/crocol/otaa001. Epub 2020 Jan 23.
Zinc (Zn) and copper (Cu) are trace elements that serve as cofactors in catalytic processes with impact on immune responses. In patients with inflammatory bowel disease (IBD), decreased levels of serum Zn and Cu have been observed. Here, we investigated the effect of inflammation on serum concentrations of these trace elements in patients with IBD.
In this cross-sectional study, 98 patients with Crohn disease (CD) and 56 with ulcerative colitis (UC) were prospectively enrolled. Disease activity parameters, such as C-reactive protein (CRP) and fecal calprotectin (FC) were compared to serum Zn, Cu, and Cu/Zn ratio.
Zinc insufficiency was observed in 11.2% of patients with CD and 14.3% with UC, Cu insufficiency in 20.4% with CD and 7.1% with UC. Anemia, hypoalbuminemia, increased FC, and elevated CRP were more frequently present in Zn-insufficient patients with IBD. In contrast, lower serum CRP values and a trend to lower FC were observed in Cu-insufficient patients. In multiple linear regression models adjusted for age, gender, and serum albumin, CRP positively correlated with serum Cu ( < 0.001) and the Cu/Zn ratio in both CD and UC ( < 0.001) but not with serum Zn concentrations. FC levels correlated only with the Cu/Zn ratio in patients with UC ( < 0.038).
Systemic inflammation inversely affected the serum Zn and Cu concentrations and, consequently, resulted in an increased Cu/Zn ratio.
锌（Zn）和铜（Cu）是微量元素，在催化过程中作为辅助因子，对免疫反应有影响。在炎症性肠病（IBD）患者中，已观察到血清锌和铜水平降低。在此，我们研究了炎症对IBD患者这些微量元素血清浓度的影响。
在这项横断面研究中，前瞻性纳入了98例克罗恩病（CD）患者和56例溃疡性结肠炎（UC）患者。将疾病活动参数，如C反应蛋白（CRP）和粪便钙卫蛋白（FC）与血清锌、铜及铜/锌比值进行比较。
在11.2%的CD患者和14.3%的UC患者中观察到锌缺乏，20.4%的CD患者和7.1%的UC患者存在铜缺乏。IBD锌缺乏患者中贫血、低白蛋白血症、FC升高和CRP升高更为常见。相比之下，铜缺乏患者的血清CRP值较低，FC有降低趋势。在针对年龄、性别和血清白蛋白进行校正的多元线性回归模型中，CRP与CD和UC患者的血清铜（<0.001）及铜/锌比值（<0.001）呈正相关，但与血清锌浓度无关。FC水平仅与UC患者的铜/锌比值相关（<0.038）。
全身炎症对血清锌和铜浓度产生相反影响，从而导致铜/锌比值升高。
