Rosenfeld C S, Nichols G, Bodensteiner D C
Am J Clin Pathol. 1987 Apr;87(4):518-22. doi: 10.1093/ajcp/87.4.518.
A flow cytometric technic was developed to detect platelet surface-bound immunoglobulin in patients with thrombocytopenia. Elevated platelet surface IgG and/or IgM was detected in 90.9% of patients with immune thrombocytopenia purpura (ITP). False positive results occurred in 9.3% of patients with nonimmune thrombocytopenia usually associated with sepsis. False negatives occurred most frequently in adults with chronic ITP. Measurement of platelet surface immunoglobulin with this flow cytometric technic helps differentiate immune from nonimmune thrombocytopenia.
已开发出一种流式细胞术技术，用于检测血小板减少症患者血小板表面结合的免疫球蛋白。在90.9%的免疫性血小板减少性紫癜（ITP）患者中检测到血小板表面IgG和/或IgM升高。在通常与脓毒症相关的非免疫性血小板减少症患者中，9.3%出现假阳性结果。假阴性最常出现在慢性ITP成人患者中。用这种流式细胞术技术测量血小板表面免疫球蛋白有助于区分免疫性和非免疫性血小板减少症。
