Department of Microbiology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA, 19104, USA; Department of Pharmacology, College of Pharmacy, Beihua University, Jilin, China.
Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Antiviral Res. 2019 Jul;167:98-103. doi: 10.1016/j.antiviral.2019.04.011. Epub 2019 Apr 26.
Curcumin, a polyphenol, is the main bioactive compound in dietary spice turmeric curcuma longa. It possesses anti-inflammatory, anti-oxidant and anti-neoplastic properties and shows potentials in treating or preventing particular diseases such as oxidative and inflammatory conditions, metabolic syndrome, arthritis, anxiety, hyperlipidemia and cancers. The diverse range and potential health beneficial effects has generated enthusiasm leading to intensive investigation into the phytochemical. However, a concern has been also raised if curcumin has a promiscuous bioassay profile and is a Pan-Assay INterference compound (PAINS). Here we present evidence indicating that curcumin is not a PAINS, but an inhibitor to APE1 redox function that affects many genes and pathways. This discovery explains the wide range of effects of curcumin on diverse human diseases and predicts a potential application in treatment of viral infection and virus-associated cancer. As a proof-of-concept, we demonstrated that curcumin is able to efficiently block Kaposi's sarcoma-associated herpesvirus replication and inhibit the pathogenic processes of angiogenesis and cell invasion.
姜黄素是一种多酚类物质，是食用香料姜黄中的主要生物活性化合物。它具有抗炎、抗氧化和抗肿瘤特性，并显示出在治疗或预防某些疾病方面的潜力，如氧化和炎症状态、代谢综合征、关节炎、焦虑、高血脂和癌症。其广泛的范围和潜在的健康有益效果引起了人们的兴趣，从而对植物化学物质进行了深入研究。然而，人们也担心姜黄素是否具有混杂的生物测定特征，是否是泛分析干扰化合物（PAINS）。在这里，我们提供的证据表明，姜黄素不是 PAINS，而是 APE1 氧化还原功能的抑制剂，会影响许多基因和途径。这一发现解释了姜黄素对多种人类疾病的广泛影响，并预测了其在治疗病毒感染和病毒相关癌症方面的潜在应用。作为一个概念验证，我们证明了姜黄素能够有效地阻断卡波济肉瘤相关疱疹病毒的复制，并抑制血管生成和细胞侵袭的致病过程。
