Post-Graduate School, Hunan University of Chinese Medicine, Changsha 410208, China.
The First Clinical College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha 410007, China.
Molecules. 2022 Jul 8;27(14):4400. doi: 10.3390/molecules27144400.
Curcumin is the most important active component in turmeric extracts. Curcumin, a natural monomer from plants has received a considerable attention as a dietary supplement, exhibiting evident activity in a wide range of human pathological conditions. In general, curcumin is beneficial to human health, demonstrating pharmacological activities of anti-inflammation and antioxidation, as well as antitumor and immune regulation activities. Curcumin also presents therapeutic potential in neurodegenerative, cardiovascular and cerebrovascular diseases. In this review article, we summarize the advancements made in recent years with respect to curcumin as a biologically active agent in malignant tumors, Alzheimer's disease (AD), hematological diseases and viral infectious diseases. We also focus on problems associated with curcumin from basic research to clinical translation, such as its low solubility, leading to poor bioavailability, as well as the controversy surrounding the association between curcumin purity and effect. Through a review and summary of the clinical research on curcumin and case reports of adverse effects, we found that the clinical transformation of curcumin is not successful, and excessive intake of curcumin may have adverse effects on the kidneys, heart, liver, blood and immune system, which leads us to warn that curcumin has a long way to go from basic research to application transformation.
姜黄素是姜黄提取物中最重要的活性成分。姜黄素是一种天然植物单体，作为膳食补充剂受到了相当多的关注，在多种人类病理状况下表现出明显的活性。一般来说，姜黄素对人体健康有益，具有抗炎、抗氧化、抗肿瘤和免疫调节等药理活性。姜黄素在神经退行性疾病、心血管疾病和脑血管疾病方面也具有治疗潜力。在这篇综述文章中，我们总结了近年来在姜黄素作为一种生物活性物质在恶性肿瘤、阿尔茨海默病（AD）、血液疾病和病毒感染性疾病中的研究进展。我们还重点关注了从基础研究到临床转化过程中与姜黄素相关的问题，如姜黄素的低溶解度导致生物利用度差，以及姜黄素纯度与效果之间的关系存在争议。通过对姜黄素的临床研究和不良反应病例报告的回顾和总结，我们发现姜黄素的临床转化并不成功，过量摄入姜黄素可能对肾脏、心脏、肝脏、血液和免疫系统产生不良影响，这使我们警告说，从基础研究到应用转化，姜黄素还有很长的路要走。
