Ghazanshahi S D, Marmarelis V Z, Yamashiro S M
Ann Biomed Eng. 1986;14(6):525-42. doi: 10.1007/BF02484470.
High-frequency ventilation (HFV) as a form of artificial respiration has attracted interest in recent years as a means of reducing the risk of barotrauma in clinical applications. This paper explores the high-frequency dynamics of the gas exchange system in order to obtain mathematical models that allow optimization studies aimed at answering the question: What is the optimum ventilatory waveform that secures a certain level of gas exchange while minimizing the resulting fluctuations in pleural or alveolar pressure? Two classes of input are considered: sinusoids and band-limited white noise. A model for the dynamic relation between tracheal flow and CO2 tension is obtained from experimental data which, in combination with existing models relating tracheal flow to pleural or alveolar pressure, allows optimization of the input flow waveform for a given level of CO2 elimination rate. The developed relation between CO2 elimination rate and input was verified by experimentally measured arterial CO2 tension.
高频通气（HFV）作为一种人工呼吸形式，近年来作为降低临床应用中气压伤风险的一种手段而受到关注。本文探讨气体交换系统的高频动力学，以获得数学模型，从而进行优化研究，旨在回答以下问题：能确保一定水平的气体交换同时使胸膜或肺泡压力波动最小化的最佳通气波形是什么？考虑了两类输入：正弦波和带限白噪声。气管流量与二氧化碳分压之间的动态关系模型是从实验数据中获得的，该模型与将气管流量与胸膜或肺泡压力相关联的现有模型相结合，能够针对给定的二氧化碳清除率水平优化输入流量波形。通过实验测量的动脉二氧化碳分压验证了所建立的二氧化碳清除率与输入之间的关系。
