Oberon Sciences Israel, Israel.
Oberon Sciences Israel, Israel; Gastroenterology and Liver Units, Department of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Mol Immunol. 2019 Jul;111:73-82. doi: 10.1016/j.molimm.2019.04.014. Epub 2019 May 6.
Microtubules (MTs) are tubular polymers of tubulin that are highly dynamic and found throughout the cytoplasm. MTs are involved in maintaining cell structure and, together with microfilaments and intermediate filaments, form the cytoskeleton. Recent findings on MT structure and function contributed to the understanding of their potential role as players in the innate and adaptive immune systems. Additionally, studies suggest an essential role for these cellular structures in the gut. Here, we review recent data on interactions between MT and various arms of the immune system and propose a model that represents gut MTs as potential targets for immunotherapy, and specifically for oral immunotherapy.
微管（MTs）是微管蛋白的管状聚合物，具有高度的动态性，存在于细胞质的各个部位。MTs 参与维持细胞结构，与微丝和中间丝一起构成细胞骨架。最近对 MT 结构和功能的研究有助于理解它们作为固有和适应性免疫系统参与者的潜在作用。此外，研究表明这些细胞结构在肠道中具有重要作用。在这里，我们回顾了 MT 与免疫系统各个分支之间相互作用的最新数据，并提出了一个模型，该模型将肠道 MT 作为免疫治疗，特别是口服免疫治疗的潜在靶点。
