Fourniat J, Djaballi Z, Maccario J, Bourlioux P, German A
Ann Rech Vet. 1986;17(4):401-7.
After oral administration of 10(2) to 10(5) CFU of Escherichia coli B41 (0101:K 99+:ST+) to 24-48 h old suckling mice (Swiss OF1), a 80 to 100% mortality rate is observed within three days. We compared the effect of the oral treatment with a lyophilized preparation of heat-killed Lactobacillus acidophilus and with sterile water on the mortality rate of newborn mice. In six out of seven assays, the heat-killed L. acidophilus administration extended survival of infected suckling mice (P ranging from 0.019 to less than 0.001). In another test, result was contradictory. A global analysis indicated that the two treatments were statistically different (P less than 0.001). Lactic acid was unable to induce protection.
给24至48小时大的哺乳小鼠（瑞士OF1）口服10(2)至10(5) 个大肠杆菌B41（0101:K 99+:ST+）的菌落形成单位后，在三天内观察到死亡率为80%至100%。我们比较了口服冻干的热灭活嗜酸乳杆菌制剂和无菌水对新生小鼠死亡率的影响。在七次试验中的六次中，给予热灭活嗜酸乳杆菌可延长受感染哺乳小鼠的存活时间（P值范围为0.019至小于0.001）。在另一项试验中，结果相互矛盾。综合分析表明，两种处理在统计学上有差异（P小于0.001）。乳酸无法诱导产生保护作用。
