Bertin A
Ann Rech Vet. 1981;12(2):137-41.
Effects of chlorpromazine and propranolol were tested in infant mice model of Enterotoxigenic Escherichia coli diarrhea. Reference strain B41 inoculated orally from 18 h to 48 h after birth causes death of almost all animals in less than 48 h. Both drugs, which are known to reverse submaximal induced secretion by heat-stable toxin in the suckling mouse assay, used as single treatment, were able to extend the survival of mice.
在产毒性大肠杆菌腹泻的幼鼠模型中测试了氯丙嗪和普萘洛尔的效果。出生后18小时至48小时口服接种的参考菌株B41可在不到48小时内导致几乎所有动物死亡。这两种药物在乳鼠试验中已知可逆转热稳定毒素诱导的次最大分泌，单独使用时均能够延长小鼠的存活时间。
