Shirley Friedman, Oshri Wasserzug, Ari Derowe, Gad Fishman
Pediatric Critical Care Unit, "Dana-Dwekˮ Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv University Sackler Faculty of Medicine, 6 Weizmann St, Tel Aviv, 6423906, Israel.
Department of Otolaryngology Head and Neck Surgery and Maxillofacial Surgery, Tel Aviv Sourasky Medical Center, Tel Aviv University Sackler Faculty of Medicine, 6 Weizmann St, Tel Aviv, 6423906, Israel.
Int J Pediatr Otorhinolaryngol. 2019 Jul;122:175-179. doi: 10.1016/j.ijporl.2019.04.017. Epub 2019 Apr 16.
Dysphonia and stridor are not infrequent in the pediatric population. Awake nasolaryngoscopy (ANL) is the primary diagnostic procedure used to evaluate a child with stridor and/or dysphonia. The major limitation of this technique is poor cooperation in children, resulting in inadequate visualization of the larynx. Ultrasound is a widely used noninvasive imaging modality that has yet to be applied to the laryngeal examination. Our goal was to investigate the feasibility and diagnostic potential of laryngeal ultrasound (LUS) in cases of pediatric stridor and/or dysphonia.
Prospective blinded cohort study of infants and children 0-16 years of age referred for ANL due to voice disorders and/or stridor. Prior knowledge of the etiology was considered an exclusion criterion.
LUS concurred with the ANL in the diagnosis of abnormal vs normal larynx in 28/32 children that were recruited. LUS had a sensitivity and specificity of 87% (95% CI: 69%-96%) and 100% (95% CI: 16%-100%) respectively, for diagnosing overall laryngeal disorders in comparison to ANL. LUS also had an area under the receiver operating characteristic (ROC) curve (AUC) of 0.93, (P = 0.04, 95% CI: 0.84-1).
LUS may be applied as an adjuvant diagnostic tool for ruling in laryngeal pathologies in children including dysphonia and stridor. As further experience is acquired the value of LUS in diagnosis will be better understood.
发音障碍和喘鸣在儿科人群中并不罕见。清醒状态下的鼻咽喉镜检查(ANL)是用于评估患有喘鸣和/或发音障碍儿童的主要诊断方法。该技术的主要局限性在于儿童配合度差,导致喉部可视化不充分。超声是一种广泛使用的无创成像方式,但尚未应用于喉部检查。我们的目标是研究喉部超声(LUS)在儿科喘鸣和/或发音障碍病例中的可行性和诊断潜力。
对因声音障碍和/或喘鸣而接受ANL检查的0至16岁婴幼儿及儿童进行前瞻性盲法队列研究。病因的先验知识被视为排除标准。
在招募的32名儿童中,LUS在诊断喉部正常或异常方面与ANL结果一致。与ANL相比,LUS诊断总体喉部疾病的敏感性和特异性分别为87%(95%置信区间:69%-96%)和100%(95%置信区间:16%-100%)。LUS的受试者操作特征曲线(ROC)下面积(AUC)为0.93,(P = 0.04,95%置信区间:0.84-1)。
LUS可作为辅助诊断工具,用于确诊包括发音障碍和喘鸣在内的儿童喉部病变。随着获得更多经验,LUS在诊断中的价值将得到更好的理解。