Laboratory of Molecular Biology, Centre for Innovative Research in Medical and Natural Sciences, Faculty of Medicine, University of Rzeszow, 35-959 Rzeszow, Poland.
Institute of Nursing and Health Sciences, Faculty of Medicine, University of Rzeszow, 35-959 Rzeszow, Poland.
Int J Environ Res Public Health. 2019 Apr 27;16(9):1489. doi: 10.3390/ijerph16091489.
encodes the protein α-actinin-3, which affects the muscle phenotype. In the present study, we examined the association of R577X polymorphism with body somatotype and cardiorespiratory fitness in young, healthy adults. The study group included 304 young adults, in whom cardiorespiratory fitness was evaluated and the maximum oxygen uptake was determined directly. The somatotype components were calculated according to the Heath-Carter method. Genotyping for the gene was performed using a polymerase chain reaction followed by high-resolution melting analysis. In the female group, a lower maximal heart rate (HRmax) was more strongly associated with the RR genotype ( = 0.0216) than with the RX and XX genotypes. In the male group, the RX genotype, as compared with other genotypes, tended to be associated with a lower percentage of adipose tissue ( = 0.0683), as also reflected by the body mass index ( = 0.0816). gene polymorphism may affect cardiorespiratory fitness. Our analysis of gene polymorphism does not clearly illustrate the relationships among genotype, body composition, and somatotype in young, healthy adults.
该基因编码肌动蛋白-3，影响肌肉表型。本研究旨在探讨年轻健康成年人中 R577X 多态性与体体型和心肺功能适应性的关系。研究组包括 304 名年轻成年人，评估了他们的心肺功能适应性并直接测定最大摄氧量。采用 Heath-Carter 方法计算体型成分。采用聚合酶链反应结合高分辨率熔解分析进行基因分型。在女性组中，较低的最大心率（HRmax）与 RR 基因型（ = 0.0216）的相关性明显强于 RX 和 XX 基因型。在男性组中，与其他基因型相比，RX 基因型与脂肪组织百分比较低（ = 0.0683）相关，体重指数（ = 0.0816）也反映了这一点。基因多态性可能影响心肺功能适应性。我们对基因多态性的分析并未清楚地阐明年轻健康成年人中基因型、身体成分和体型之间的关系。
