Rabkin M S, Kjeldsberg C R
Arch Pathol Lab Med. 1987 Apr;111(4):337-8.
Epithelial membrane antigen (EMA) appears to be a marker of activation, proliferation, and/or neoplasia in some epithelial and nonepithelial cells, including histiocytes. We performed immunoperoxidase stains for EMA on a variety of histiocytic lesion specimens, including specimens from two cases of interdigitating reticulum cell lymphoma, 12 cases of histiocytosis X, seven cases of sarcoidosis, five cases of granuloma annulare, 13 juvenile xanthogranulomas, two reticulohistiocytomas, five xanthelasmas, three dermatopathic lymph nodes, and three foreign body reactions. Only the two cases of interdigitating reticulum cell lymphoma and two of the 12 cases of histiocytosis X exhibited significant EMA positivity. These findings may prove useful in the differential diagnosis of histiocytic lesions.
上皮膜抗原（EMA）似乎是某些上皮细胞和非上皮细胞（包括组织细胞）激活、增殖和/或肿瘤形成的标志物。我们对多种组织细胞病变标本进行了EMA免疫过氧化物酶染色，包括两例指状突网状细胞淋巴瘤、12例组织细胞增多症X、7例结节病、5例环状肉芽肿、13例幼年性黄色肉芽肿、2例网状组织细胞瘤、5例睑黄瘤、3例皮肤型淋巴结病和3例异物反应的标本。仅两例指状突网状细胞淋巴瘤以及12例组织细胞增多症X中的两例表现出明显的EMA阳性。这些发现可能对组织细胞病变的鉴别诊断有用。
